Open Access

Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review)

  • Authors:
    • Wenjuan Zeng
    • Haohan Liu
    • Yuanhao Mao
    • Shihao Jiang
    • Hao Yi
    • Zitong Zhang
    • Menghui Wang
    • Zhen Zong
  • View Affiliations

  • Published online on: July 25, 2024     https://doi.org/10.3892/ijo.2024.5673
  • Article Number: 85
  • Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Globally, colorectal cancer (CRC) is the third most common type of cancer. CRC has no apparent symptoms in the early stages of disease, and most patients receive a confirmed diagnosis in the middle or late disease stages. The incidence of CRC continues to increase, and the affected population tends to be younger. Therefore, determining how to achieve an early CRC diagnosis and treatment has become a top priority for prolonging patient survival. Myeloid‑derived suppressor cells (MDSCs) are a group of bone marrow‑derived immuno‑negative regulatory cells that are divided into two subpopulations, polymorphonuclear‑MDSCs and monocytic‑MDSCs, based on their phenotypic similarities to neutrophils and monocytes, respectively. These cells can inhibit the immune response and promote cancer cell metastasis in the tumour microenvironment (TME). A large aggregation of MDSCs in the TME is often a marker of cancer and a poor prognosis in inflammatory diseases of the intestine (such as colonic adenoma and ulcerative colitis). In the present review, the phenotypic classification of MDSCs in the CRC microenvironment are first discussed. Then, the amplification, role and metastatic mechanism of MDSCs in the CRC TME are described, focusing on genes, gene modifications, proteins and the intestinal microenvironment. Finally, the progress in CRC‑targeted therapies that aim to modulate the quantity, function and structure of MDSCs are summarized in the hope of identifying potential screening markers for CRC and improving CRC prognosis and therapeutic options.

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September-2024
Volume 65 Issue 3

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Copy and paste a formatted citation
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Spandidos Publications style
Zeng W, Liu H, Mao Y, Jiang S, Yi H, Zhang Z, Wang M and Zong Z: Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review). Int J Oncol 65: 85, 2024
APA
Zeng, W., Liu, H., Mao, Y., Jiang, S., Yi, H., Zhang, Z. ... Zong, Z. (2024). Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review). International Journal of Oncology, 65, 85. https://doi.org/10.3892/ijo.2024.5673
MLA
Zeng, W., Liu, H., Mao, Y., Jiang, S., Yi, H., Zhang, Z., Wang, M., Zong, Z."Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review)". International Journal of Oncology 65.3 (2024): 85.
Chicago
Zeng, W., Liu, H., Mao, Y., Jiang, S., Yi, H., Zhang, Z., Wang, M., Zong, Z."Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review)". International Journal of Oncology 65, no. 3 (2024): 85. https://doi.org/10.3892/ijo.2024.5673