Open Access

Functions and mechanisms of RNA m6A regulators in breast cancer (Review)

  • Authors:
    • Yibei Yang
    • Feng Gao
    • Lanqi Ren
    • Ning Ren
    • Junjie Pan
    • Qiaoping Xu
  • View Affiliations

  • Published online on: July 26, 2024     https://doi.org/10.3892/ijo.2024.5674
  • Article Number: 86
  • Copyright : © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Breast cancer (BC) is a major malignant tumor in females and the incidence rate of BC has increased worldwide in recent years. N6‑methyladenosine (m6A) is a methylation modification that occurs extensively in eukaryotic RNA. The abnormal expression of m6A and related regulatory proteins can activate or inhibit certain signal pathways or oncogenes, thus affecting the proliferation, metastasis and prognosis of BC. Numerous studies have shown that m6A regulator disorder exists in BC, and this disorder can be reversed. Therefore, m6A is predicted as a potential therapeutic target for BC. However, the molecular mechanism of m6A RNA methylation regulating the occurrence and development of BC has not been comprehensively elucidated. In this review article, the functions of various m6A regulators and the specific mechanisms of certain regulators of the progress of BC were summarized. Furthermore, the dual role of RNA methylation in tumor progression was discussed, concluding that RNA methylation can not only lead to tumorigenesis but at times give rise to inhibition of tumor formation. In addition, further comprehensive analysis on mechanisms of m6A regulators in BC is conducive to screening effective potential targets and formulating targeted treatment strategies, which will provide new methods for the prevention and treatment of BC.

Related Articles

Journal Cover

September-2024
Volume 65 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Gao F, Ren L, Ren N, Pan J and Xu Q: Functions and mechanisms of RNA m<sup>6</sup>A regulators in breast cancer (Review). Int J Oncol 65: 86, 2024
APA
Yang, Y., Gao, F., Ren, L., Ren, N., Pan, J., & Xu, Q. (2024). Functions and mechanisms of RNA m<sup>6</sup>A regulators in breast cancer (Review). International Journal of Oncology, 65, 86. https://doi.org/10.3892/ijo.2024.5674
MLA
Yang, Y., Gao, F., Ren, L., Ren, N., Pan, J., Xu, Q."Functions and mechanisms of RNA m<sup>6</sup>A regulators in breast cancer (Review)". International Journal of Oncology 65.3 (2024): 86.
Chicago
Yang, Y., Gao, F., Ren, L., Ren, N., Pan, J., Xu, Q."Functions and mechanisms of RNA m<sup>6</sup>A regulators in breast cancer (Review)". International Journal of Oncology 65, no. 3 (2024): 86. https://doi.org/10.3892/ijo.2024.5674