Open Access

The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression (Review)

  • Authors:
    • Aziz Ur Rehman Aziz
    • Jianing Zhang
    • Chan Zhang
    • Xiaohui Yu
    • Daqing Wang
  • View Affiliations

  • Published online on: July 18, 2024     https://doi.org/10.3892/mco.2024.2765
  • Article Number: 67
  • Copyright: © Aziz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is a significant global health concern, with a substantial portion of cases attributed to human papillomavirus (HPV) infection. Recent advancements in molecular profiling have identified distinct subtypes of cervical cancer based on their genomic alterations. One such subgroup is neurotrophic tropomyosin receptor kinase (NTRK) fusion‑positive cervical cancers, characterized by gene fusions involving the NTRK genes. Although both NTRK fusion genes and HPV infections are independently recognized as significant risk factors in cervical cancer, their interplay and mutual effects on cancer progression are not yet fully understood. The present review is the first of its kind to explore the potential interplay between NTRK fusion genes and HPV infections. It surveys in detail how their combined effect can influence the signaling pathways during cervical cancer development and progression. Moreover, the present study discussed the clinical features, histopathological examinations, treatment procedures and follow‑up outcomes of NTRK‑fusion gene‑positive cervical cancer. The present review may help in the understanding of the management and treatment of such rare, lethal and resistant cervical cancers.

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October-2024
Volume 21 Issue 4

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Copy and paste a formatted citation
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Spandidos Publications style
Aziz A, Zhang J, Zhang C, Yu X and Wang D: The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression (Review). Mol Clin Oncol 21: 67, 2024
APA
Aziz, A., Zhang, J., Zhang, C., Yu, X., & Wang, D. (2024). The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression (Review). Molecular and Clinical Oncology, 21, 67. https://doi.org/10.3892/mco.2024.2765
MLA
Aziz, A., Zhang, J., Zhang, C., Yu, X., Wang, D."The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression (Review)". Molecular and Clinical Oncology 21.4 (2024): 67.
Chicago
Aziz, A., Zhang, J., Zhang, C., Yu, X., Wang, D."The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression (Review)". Molecular and Clinical Oncology 21, no. 4 (2024): 67. https://doi.org/10.3892/mco.2024.2765