Open Access

Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy

  • Authors:
    • Itaru Hashimoto
    • Keisuke Komori
    • Yukio Maezawa
    • Shinsuke Nagasawa
    • Taiichi Kawabe
    • Toru Aoyama
    • Tsutomu Hayashi
    • Takanobu Yamada
    • Tsutomu Sato
    • Takashi Ogata
    • Haruhiko Cho
    • Takaki Yoshikawa
    • Norio Yukawa
    • Yasushi Rino
    • Aya Saito
    • Takashi Oshima
  • View Affiliations

  • Published online on: July 25, 2024     https://doi.org/10.3892/ol.2024.14591
  • Article Number: 458
  • Copyright: © Hashimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association of computed tomography (CT)‑derived skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) with postoperative prognosis in patients with gastric cancer (GC) remains unknown. Therefore, the present study aimed to assess the association between SMI and SMD with 5‑year overall survival (OS) and recurrence‑free survival (RFS) in patients with GC. SMI and SMD were measured preoperatively in patients who underwent gastrectomy. Patients were categorized into Groups 1 (high SMI and SMD), 2 (high SMI or SMD) and 3 (low SMI and SMD). OS and RFS rates were assessed using Kaplan‑Meier analysis and the log‑rank test. Among 459 patients, OS and RFS rates were significantly lower in the low‑SMD group than in the high‑SMD group (OS, 83.4% vs. 88.8%, respectively; P=0.04 and RFS, 80.5% vs. 87.2%, respectively; P=0.02). OS and RFS rates were also significantly lower in Group 3 than in Groups 2 and 1 (P=0.006). Multivariate analysis revealed that a low SMI and SMD (Group 3) was a significant independent prognostic factor for OS [hazard ratio (HR), 2.32; 95% confidence interval (CI), 1.17‑4.59; P=0.016] and RFS (HR, 2.28; 95% CI, 1.19‑4.37; P=0.013). In summary, low SMI and SMD values may be useful postoperative prognostic indicators for patients with GC.

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October-2024
Volume 28 Issue 4

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Spandidos Publications style
Hashimoto I, Komori K, Maezawa Y, Nagasawa S, Kawabe T, Aoyama T, Hayashi T, Yamada T, Sato T, Ogata T, Ogata T, et al: Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy. Oncol Lett 28: 458, 2024
APA
Hashimoto, I., Komori, K., Maezawa, Y., Nagasawa, S., Kawabe, T., Aoyama, T. ... Oshima, T. (2024). Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy. Oncology Letters, 28, 458. https://doi.org/10.3892/ol.2024.14591
MLA
Hashimoto, I., Komori, K., Maezawa, Y., Nagasawa, S., Kawabe, T., Aoyama, T., Hayashi, T., Yamada, T., Sato, T., Ogata, T., Cho, H., Yoshikawa, T., Yukawa, N., Rino, Y., Saito, A., Oshima, T."Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy". Oncology Letters 28.4 (2024): 458.
Chicago
Hashimoto, I., Komori, K., Maezawa, Y., Nagasawa, S., Kawabe, T., Aoyama, T., Hayashi, T., Yamada, T., Sato, T., Ogata, T., Cho, H., Yoshikawa, T., Yukawa, N., Rino, Y., Saito, A., Oshima, T."Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy". Oncology Letters 28, no. 4 (2024): 458. https://doi.org/10.3892/ol.2024.14591