Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages

  • Authors:
    • Yan-Fang Xian
    • Yu-Cui Li
    • Siu-Po Ip
    • Zhi-Xiu Lin
    • Xiao-Ping Lai
    • Zi-Ren Su
  • View Affiliations

  • Published online on: March 21, 2011     https://doi.org/10.3892/etm.2011.233
  • Pages: 545-550
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pogostemonis Herba has long been used in traditional Chinese medicine for the treatment of inflammation-related disorders. Patchouli alcohol (PA) isolated from Pogostemonis Herba is a tricyclic sesquiterpene that is known to exert a variety of pharmacological activities. The present study aimed to investigate the anti-inflammatory effect of PA on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Pre-treatment with PA at concentrations of 10, 20 or 40 µM dose-dependently decreased the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, nitric oxide (NO) and prostaglandin E2 in LPS-stimulated RAW264.7 cells. In addition, PA treatment also reversed the increased mRNA expression of TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells. These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-α, IL-1β, IL-6, iNOS and COX-2.
View Figures
View References

Related Articles

Journal Cover

May-June 2011
Volume 2 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xian Y, Li Y, Ip S, Lin Z, Lai X and Su Z: Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages. Exp Ther Med 2: 545-550, 2011.
APA
Xian, Y., Li, Y., Ip, S., Lin, Z., Lai, X., & Su, Z. (2011). Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages. Experimental and Therapeutic Medicine, 2, 545-550. https://doi.org/10.3892/etm.2011.233
MLA
Xian, Y., Li, Y., Ip, S., Lin, Z., Lai, X., Su, Z."Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages". Experimental and Therapeutic Medicine 2.3 (2011): 545-550.
Chicago
Xian, Y., Li, Y., Ip, S., Lin, Z., Lai, X., Su, Z."Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages". Experimental and Therapeutic Medicine 2, no. 3 (2011): 545-550. https://doi.org/10.3892/etm.2011.233