Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review)

  • Authors:
    • Ruth Magaye
    • Jinshun Zhao
    • Linda Bowman
    • Min Ding
  • View Affiliations

  • Published online on: August 7, 2012     https://doi.org/10.3892/etm.2012.656
  • Pages: 551-561
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Abstract

The nanotechnology industry has matured and expanded at a rapid pace in the last decade, leading to the research and development of nanomaterials with enormous potential. The largest source of these nanomaterials is the transitional metals. It has been revealed that numerous properties of these nano-sized elements are not present in their bulk states. The nano size of these particles means they are easily transported into biological systems, thus, raising the question of their effects on the susceptible systems. Although advances have been made and insights have been gained on the effect of transitional metals on susceptible biological systems, there still is much ground to be covered, particularly with respect to our knowledge on the genotoxic and carcinogenic effects. Therefore, this review intends to summarize the current knowledge on the genotoxic and carcinogenic potential of cobalt-, nickel- and copper-based nanoparticles indicated in in vitro and in vivo mammalian studies. In the present review, we briefly state the sources, use and exposure routes of these nanoparticles and summarize the current literature findings on their in vivo and in vitro genotoxic and carcinogenic effects. Due to the increasing evidence of their role in carcinogenicity, we have also included studies that have reported epigenetic factors, such as abnormal apoptosis, enhanced oxidative stress and pro-inflammatory effects involving these nanoparticles.
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October 2012
Volume 4 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Magaye R, Zhao J, Bowman L and Ding M: Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review). Exp Ther Med 4: 551-561, 2012.
APA
Magaye, R., Zhao, J., Bowman, L., & Ding, M. (2012). Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review). Experimental and Therapeutic Medicine, 4, 551-561. https://doi.org/10.3892/etm.2012.656
MLA
Magaye, R., Zhao, J., Bowman, L., Ding, M."Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review)". Experimental and Therapeutic Medicine 4.4 (2012): 551-561.
Chicago
Magaye, R., Zhao, J., Bowman, L., Ding, M."Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review)". Experimental and Therapeutic Medicine 4, no. 4 (2012): 551-561. https://doi.org/10.3892/etm.2012.656