Open Access

Genetics of schizophrenia (Review)

  • Authors:
    • Simona Corina Trifu
    • Bianca Kohn
    • Andrei Vlasie
    • Bogdan-Eduard Patrichi
  • View Affiliations

  • Published online on: July 7, 2020     https://doi.org/10.3892/etm.2020.8973
  • Pages: 3462-3468
  • Copyright: © Trifu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A comprehensive review of the body of genetic studies on schizophrenia seems even more daunting than the battle a psychiatrist wages daily in the office with her archenemy of a thousand faces. The following article reunites some genetic, epigenetic and environmental factors of schizophrenia from revered and vast studies in a chronological and progressive fashion. Twin studies set the basics of heritability and a particular study by Davis and Phelps considers the widely ignored influence of prenatal environment in the development of schizophrenia. Mostly ignited by linkage studies, candidate gene studies explore further by fine‑mapping the hypothesized variants [mostly in the forms single nucleotide polymorphisms (SNPs) and less but with greater impact copy number variations (CNVs)] associated with the disease. Genome‑wide association studies (GWAS) increase considerably the sample sizes and thus the validity of the results, while the next‑generation sequencing (NGS) attain the highest yet unreplicated level of validity results.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Trifu SC, Kohn B, Vlasie A and Patrichi B: Genetics of schizophrenia (Review). Exp Ther Med 20: 3462-3468, 2020.
APA
Trifu, S.C., Kohn, B., Vlasie, A., & Patrichi, B. (2020). Genetics of schizophrenia (Review). Experimental and Therapeutic Medicine, 20, 3462-3468. https://doi.org/10.3892/etm.2020.8973
MLA
Trifu, S. C., Kohn, B., Vlasie, A., Patrichi, B."Genetics of schizophrenia (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3462-3468.
Chicago
Trifu, S. C., Kohn, B., Vlasie, A., Patrichi, B."Genetics of schizophrenia (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3462-3468. https://doi.org/10.3892/etm.2020.8973