Open Access

Functional and structural neurodegenerative activities of Ankaferd BloodStopper in a mouse sciatic nerve model

  • Authors:
    • Ramazan Üstün
    • Elif Kaval Oğuz
    • Ayşe Şeker
    • Filiz Taspinar
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  • Published online on: July 2, 2024     https://doi.org/10.3892/etm.2024.12634
  • Article Number: 345
  • Copyright: © Üstün et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Traumatic and postoperative hemorrhages are life‑threatening complications. Ankaferd BloodStopper (ABS) is a potent topical hemostatic agent to stop bleeding. However, ABS is associated with nerve toxicity. The present study aimed to investigate the functional and structural neurodegenerative effects of ABS in a mouse model. A total of 30 male BALB/c mice, aged 6‑8 weeks, were randomly divided into control group (no treatment), a sham group (treated with saline) and an experimental group (treated with ABS). In the saline and the ABS groups, the right sciatic nerve was surgically exposed and treated with saline or ABS, respectively. No surgical procedure was performed in the control group. On day 7 post‑treatment, functional changes of the sciatic nerve were evaluated by a horizontal ladder rung walking task. Structural changes were assessed with immunohistochemistry. In the horizontal ladder rung walking test, the gait impairment was proportional to the severity of sciatic nerve damage, with the ABS group showing a significantly higher rate of errors than the control and saline groups. Immunohistochemistry demonstrated extensive degeneration and deformation in the axons and myelin sheath of the sciatic nerve in the ABS group. The results provide compelling evidence for the neurotoxicity of ABS.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Üstün R, Oğuz EK, Şeker A and Taspinar F: Functional and structural neurodegenerative activities of Ankaferd BloodStopper in a mouse sciatic nerve model. Exp Ther Med 28: 345, 2024.
APA
Üstün, R., Oğuz, E.K., Şeker, A., & Taspinar, F. (2024). Functional and structural neurodegenerative activities of Ankaferd BloodStopper in a mouse sciatic nerve model. Experimental and Therapeutic Medicine, 28, 345. https://doi.org/10.3892/etm.2024.12634
MLA
Üstün, R., Oğuz, E. K., Şeker, A., Taspinar, F."Functional and structural neurodegenerative activities of Ankaferd BloodStopper in a mouse sciatic nerve model". Experimental and Therapeutic Medicine 28.3 (2024): 345.
Chicago
Üstün, R., Oğuz, E. K., Şeker, A., Taspinar, F."Functional and structural neurodegenerative activities of Ankaferd BloodStopper in a mouse sciatic nerve model". Experimental and Therapeutic Medicine 28, no. 3 (2024): 345. https://doi.org/10.3892/etm.2024.12634