Open Access

Partial response of hepatocellular carcinoma to lenalidomide following progression in response to lenvatinib: A case report

  • Authors:
    • Xu Zhang
    • Pan Liu
    • Qiang Fu
    • Qian-Kun Luo
    • Peng-Fei Yu
    • Jing-Yu Chen
    • Yu-Zhu Wang
    • Tao Qin
  • View Affiliations

  • Published online on: July 5, 2024     https://doi.org/10.3892/etm.2024.12642
  • Article Number: 352
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer. Although it has a high mortality rate, there is currently no effective treatment for HCC. Lenvatinib has traditionally been used as the first‑line treatment for advanced HCC (aHCC); however, resistance to this therapy is common. It can be difficult to select effective second‑line drugs to overcome lenvatinib resistance when treating aHCC. For patients with aHCC, poor treatment efficacy can result in patients missing the optimal treatment window and can lead to an irreversible situation. Lenalidomide has begun to be used to treat HCC; however, to the best of our knowledge, its efficacy in patients with lenvatinib‑resistant HCC remains to be reported on in the literature. The present case report, to the best of our knowledge, describes the first case in the literature of a patient with lenvatinib‑resistant aHCC who achieved a partial response after the treatment regimen was switched to lenalidomide. The present case report provides a promising novel route for the treatment of lenvatinib‑resistant HCC.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Liu P, Fu Q, Luo Q, Yu P, Chen J, Wang Y and Qin T: Partial response of hepatocellular carcinoma to lenalidomide following progression in response to lenvatinib: A case report. Exp Ther Med 28: 352, 2024.
APA
Zhang, X., Liu, P., Fu, Q., Luo, Q., Yu, P., Chen, J. ... Qin, T. (2024). Partial response of hepatocellular carcinoma to lenalidomide following progression in response to lenvatinib: A case report. Experimental and Therapeutic Medicine, 28, 352. https://doi.org/10.3892/etm.2024.12642
MLA
Zhang, X., Liu, P., Fu, Q., Luo, Q., Yu, P., Chen, J., Wang, Y., Qin, T."Partial response of hepatocellular carcinoma to lenalidomide following progression in response to lenvatinib: A case report". Experimental and Therapeutic Medicine 28.3 (2024): 352.
Chicago
Zhang, X., Liu, P., Fu, Q., Luo, Q., Yu, P., Chen, J., Wang, Y., Qin, T."Partial response of hepatocellular carcinoma to lenalidomide following progression in response to lenvatinib: A case report". Experimental and Therapeutic Medicine 28, no. 3 (2024): 352. https://doi.org/10.3892/etm.2024.12642