Open Access

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

  • Authors:
    • Ilakya Selvakumar
    • Ashwini Vasudevan
    • Nirmal Perera
    • Meran Keshawa Ediriweera
    • Devipriya Nagarajan
    • Sameera Ranganath Samarakoon
    • Kamani Hemamala Tennekoon
    • Vadivel Vellingiri
  • View Affiliations

  • Published online on: February 2, 2022     https://doi.org/10.3892/ije.2022.10
  • Article Number: 1
  • Copyright: © Selvakumar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Among the different types of mango species, Mangifera indica (MI) and Mangifera zeylanica (MZ) are well known for their therapeutic potential. MI is a pharmacologically and phytochemically diverse plant. Extracts prepared from different parts (bark, leaves, roots, seeds, flowers and fruits) of MI and major mango phytochemicals have been reported to exert a range of pharmacological effects. MZ is a plant endemic to Sri Lanka. The bark of MZ has been used in the Sri Lankan traditional medicine for the treatment of various ailments and conditions, including cancer. Recently, substantial efforts have been made to provide a scientific validation for its traditional use in the treatment of cancer. The present review article describes the pharmacological activities, including anti‑inflammatory, antioxidant, anticancer, anti‑microbial, anti‑diabetic and anti‑obesity properties of MI. Furthermore, the anticancer potential of MZ bark extracts and information on compounds isolated from MZ and their bio‑activities are also described. The effects of major Mangifera compounds on epigenetic modifications have been widely studied. Therefore, the ability of Mangifera compounds to function as epigenetic drugs in the context of cancer drug discovery has become a promising area of investigation. However, an assessment of the clinical efficacy, and potential adverse and toxic effects of mango extracts is essential prior to their use in clinical practice.
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January-February 2022
Volume 2 Issue 1

Print ISSN: 2752-5406
Online ISSN:2752-5414

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Spandidos Publications style
Selvakumar I, Vasudevan A, Perera N, Ediriweera MK, Nagarajan D, Samarakoon SR, Tennekoon KH and Vellingiri V: Mangifera indica and <em>Mangifera zeylanica</em>: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review). Int J Epigen 2: 1, 2022.
APA
Selvakumar, I., Vasudevan, A., Perera, N., Ediriweera, M.K., Nagarajan, D., Samarakoon, S.R. ... Vellingiri, V. (2022). Mangifera indica and <em>Mangifera zeylanica</em>: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review). International Journal of Epigenetics, 2, 1. https://doi.org/10.3892/ije.2022.10
MLA
Selvakumar, I., Vasudevan, A., Perera, N., Ediriweera, M. K., Nagarajan, D., Samarakoon, S. R., Tennekoon, K. H., Vellingiri, V."Mangifera indica and <em>Mangifera zeylanica</em>: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)". International Journal of Epigenetics 2.1 (2022): 1.
Chicago
Selvakumar, I., Vasudevan, A., Perera, N., Ediriweera, M. K., Nagarajan, D., Samarakoon, S. R., Tennekoon, K. H., Vellingiri, V."Mangifera indica and <em>Mangifera zeylanica</em>: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)". International Journal of Epigenetics 2, no. 1 (2022): 1. https://doi.org/10.3892/ije.2022.10