Open Access

Current updates on the association between celiac disease and cancer, and the effects of the gluten‑free diet for modifying the risk (Review)

  • Authors:
    • Neetu Kalra
    • Anuska Mukerjee
    • Shreya Sinha
    • Vaishnavi Muralidhar
    • Yeliz Serin
    • Aadhya Tiwari
    • Anil K. Verma
  • View Affiliations

  • Published online on: January 24, 2022     https://doi.org/10.3892/ijfn.2022.25
  • Article Number: 2
  • Copyright: © Kalra et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Celiac disease (CD) is a chronic enteropathy caused by the ingestion of gluten in genetically susceptible individuals. CD is a common food‑related disorder with a prevalence of ~1% worldwide. Failure to follow the only available treatment, i.e., a standard gluten‑free diet (GFD), increases the risk of adverse outcomes, such as refractory CD. Studies have reported that the long‑term avoidance of a GFD may lead to the development of certain types of cancer in patients with CD. An increased risk of gastrointestinal cancers and intestinal lymphomas are associated with CD. On the other hand, recent studies have demonstrated that the risk of colon cancer, ovarian and breast cancer is low in patients with CD. It has also been demonstrated that a strict GFD exerts a positive effect in reducing the cancer risk. However, only a limited number of studies have been conducted in this area, and the outcomes of these studies warrant further verifications. The present review article summarises and discusses the possible links between CD and cancer, and the probable reasons behind their association. In addition, the present review also discusses whether a strict GFD reduces the risk of developing certain types of cancer in patients with CD.
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January-February 2022
Volume 3 Issue 1

Print ISSN: 2634-7989
Online ISSN:2634-7237

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Spandidos Publications style
Kalra N, Mukerjee A, Sinha S, Muralidhar V, Serin Y, Tiwari A and Verma AK: Current updates on the association between celiac disease and cancer, and the effects of the gluten‑free diet for modifying the risk (Review). Int J Funct Nutr 3: 2, 2022.
APA
Kalra, N., Mukerjee, A., Sinha, S., Muralidhar, V., Serin, Y., Tiwari, A., & Verma, A.K. (2022). Current updates on the association between celiac disease and cancer, and the effects of the gluten‑free diet for modifying the risk (Review). International Journal of Functional Nutrition, 3, 2. https://doi.org/10.3892/ijfn.2022.25
MLA
Kalra, N., Mukerjee, A., Sinha, S., Muralidhar, V., Serin, Y., Tiwari, A., Verma, A. K."Current updates on the association between celiac disease and cancer, and the effects of the gluten‑free diet for modifying the risk (Review)". International Journal of Functional Nutrition 3.1 (2022): 2.
Chicago
Kalra, N., Mukerjee, A., Sinha, S., Muralidhar, V., Serin, Y., Tiwari, A., Verma, A. K."Current updates on the association between celiac disease and cancer, and the effects of the gluten‑free diet for modifying the risk (Review)". International Journal of Functional Nutrition 3, no. 1 (2022): 2. https://doi.org/10.3892/ijfn.2022.25