Open Access

Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review)

  • Authors:
    • Jiaqi Guo
    • Jun Wang
    • Pei Liang
    • E Tian
    • Dan Liu
    • Zhaoqi Guo
    • Jingyu Chen
    • Yuejin Zhang
    • Zhanghong Zhou
    • Weijia Kong
    • Debbie C. Crans
    • Yisheng Lu
    • Sulin Zhang
  • View Affiliations

  • Published online on: February 23, 2024     https://doi.org/10.3892/ijmm.2024.5360
  • Article Number: 36
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The vestibular system may have a critical role in the integration of sensory information and the maintenance of cognitive function. A dysfunction in the vestibular system has a significant impact on quality of life. Recent research has provided evidence of a connection between vestibular information and cognitive functions, such as spatial memory, navigation and attention. Although the exact mechanisms linking the vestibular system to cognition remain elusive, researchers have identified various pathways. Vestibular dysfunction may lead to the degeneration of cortical vestibular network regions and adversely affect synaptic plasticity and neurogenesis in the hippocampus, ultimately contributing to neuronal atrophy and cell death, resulting in memory and visuospatial deficits. Furthermore, the extent of cognitive impairment varies depending on the specific type of vestibular disease. In the present study, the current literature was reviewed, potential causal relationships between vestibular dysfunction and cognitive performance were discussed and directions for future research were proposed.
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April-2024
Volume 53 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Guo J, Wang J, Liang P, Tian E, Liu D, Guo Z, Chen J, Zhang Y, Zhou Z, Kong W, Kong W, et al: Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review). Int J Mol Med 53: 36, 2024.
APA
Guo, J., Wang, J., Liang, P., Tian, E., Liu, D., Guo, Z. ... Zhang, S. (2024). Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review). International Journal of Molecular Medicine, 53, 36. https://doi.org/10.3892/ijmm.2024.5360
MLA
Guo, J., Wang, J., Liang, P., Tian, E., Liu, D., Guo, Z., Chen, J., Zhang, Y., Zhou, Z., Kong, W., Crans, D. C., Lu, Y., Zhang, S."Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review)". International Journal of Molecular Medicine 53.4 (2024): 36.
Chicago
Guo, J., Wang, J., Liang, P., Tian, E., Liu, D., Guo, Z., Chen, J., Zhang, Y., Zhou, Z., Kong, W., Crans, D. C., Lu, Y., Zhang, S."Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review)". International Journal of Molecular Medicine 53, no. 4 (2024): 36. https://doi.org/10.3892/ijmm.2024.5360