Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review)
- Authors:
- Maximo Berto Martinez Benitez
- Yussel Pérez Navarro
- Elisa Azuara‑Liceaga
- Angeles Tecalco Cruz
- Jesús Valdés Flores
- Lilia Lopez‑Canovas
-
Affiliations: Postgraduate Program in Genomic Sciences, Science and Technology School, Autonomous University of Mexico City, Mexico City, CP 03100, Mexico, Biochemistry Department, Center for Research and Advanced Studies, National Polytechnic Institute of Mexico, Mexico City, CP 07360, Mexico - Published online on: March 21, 2024 https://doi.org/10.3892/ijmm.2024.5368
- Article Number: 44
-
Copyright: © Benitez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
American Diabetes Association: 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2021. Diabetes Care. 44(Suppl 1): S15–S33. 2021. View Article : Google Scholar | |
Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, et al: IDF diabetes atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 183:1091192022. View Article : Google Scholar | |
Harding JL, Pavkov ME, Magliano DJ, Shaw JE and Gregg EW: Global trends in diabetes complications: A review of current evidence. Diabetologia. 62:3–16. 2019. View Article : Google Scholar | |
Prasad RB and Groop L: Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel). 6:87–123. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lyssenko V and Laakso M: Genetic screening for the risk of type 2 diabetes: Worthless or valuable? Diabetes Care. 36(Suppl 2): S120–S126. 2013. View Article : Google Scholar : PubMed/NCBI | |
Vassy JL and Meigs JB: Is Genetic testing useful to predict type 2 diabetes? Best Pract Res Clin Endocrinol Metab. 26:189–201. 2012. View Article : Google Scholar : PubMed/NCBI | |
Miranda-Lora AL, Vilchis-Gil J, Juárez-Comboni DB, Cruz M and Klünder-Klünder M: A genetic risk score improves the prediction of type 2 diabetes mellitus in mexican youths but has lower predictive utility compared with non-genetic factors. Front Endocrinol (Lausanne). 12:6478642021. View Article : Google Scholar : PubMed/NCBI | |
Willems SM, Mihaescu R, Sijbrands EJG, Van Duijn CM and Janssens AC: A methodological perspective on genetic risk prediction studies in type 2 diabetes: Recommendations for future research. Curr Diab Rep. 11:511–518. 2011. View Article : Google Scholar : PubMed/NCBI | |
Fava S and Hattersley AT: The role of genetic susceptibility in diabetic nephropathy: evidence from family studies. Nephrol Dial Transplant. 17:1543–1546. 2002. View Article : Google Scholar : PubMed/NCBI | |
Szymañski M, Barciszewska MZ, Zywicki M and Barciszewski J: Noncoding RNA transcripts. J Appl Genet. 44:1–19. 2003.PubMed/NCBI | |
Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : | |
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI | |
Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss, et al: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell. 58:870–885. 2015. View Article : Google Scholar : PubMed/NCBI | |
Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15:4092014. View Article : Google Scholar : PubMed/NCBI | |
Salzman J, Chen RE, Olsen MN, Wang PL and Brown PO: Cell-Type specific features of circular RNA expression. PLoS Genet. 9:e10037772013. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L and Chen LL: Circular intronic long noncoding RNAs. Mol Cell. 51:792–806. 2013. View Article : Google Scholar : PubMed/NCBI | |
Song P, Yang F, Jin H and Wang X: The regulation of protein translation and its implications for cancer. Signal Transduct Target Ther. 6:682021. View Article : Google Scholar : PubMed/NCBI | |
Liao W, Du J, Wang Z, Feng Q, Liao M, Liu H, Yuan K and Zeng Y: The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma. Int J Cancer. 151:337–347. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ebbesen KK, Hansen TB and Kjems J: Insights into circular RNA biology. RNA Biol. 14:1035–1045. 2017. View Article : Google Scholar : | |
Chen LL: The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 17:205–211. 2016. View Article : Google Scholar : PubMed/NCBI | |
Qu S, Zhong Y, Shang R, Zhang X, Song W, Kjems J and Li H: The emerging landscape of circular RNA in life processes. RNA Biol. 14:992–999. 2017. View Article : Google Scholar : | |
Barrett SP and Salzman J: Circular RNAs: Analysis, expression and potential functions. Development. 143:1838–1847. 2016. View Article : Google Scholar : PubMed/NCBI | |
Liu CX and Chen LL: Circular RNAs: Characterization, cellular roles, and applications. Cell. 185:2016–2034. 2022. View Article : Google Scholar : PubMed/NCBI | |
Chi T, Lin J, Wang M, Zhao Y, Liao Z and Wei P: Non-Coding RNA as biomarkers for type 2 diabetes development and clinical management. Front Endocrinol (Lausanne). 12:6300322021. View Article : Google Scholar : PubMed/NCBI | |
Wang F and Zhang M: Circ_001209 aggravates diabetic retinal vascular dysfunction through regulating miR-15b-5p/COL12A1. J Transl Med. 19:2942021. View Article : Google Scholar : PubMed/NCBI | |
Fan W, Pang H, Xie Z, Huang G and Zhou Z: Circular RNAs in diabetes mellitus and its complications. Front Endocrinol (Lausanne). 13:8856502022. View Article : Google Scholar : PubMed/NCBI | |
Patil NS, Feng B, Su Z, Castellani CA and Chakrabarti S: Circular RNA mediated gene regulation in chronic diabetic complications. Sci Rep. 11:237662021. View Article : Google Scholar : PubMed/NCBI | |
Tu C, Wang L, Wei L and Jiang Z: The role of circular RNA in diabetic nephropathy. Int J Med Sci. 19:916–923. 2022. View Article : Google Scholar : PubMed/NCBI | |
Liu R, Zhang M and Ge Y: Circular RNA HIPK3 exacerbates diabetic nephropathy and promotes proliferation by sponging miR-185. Gene. 765:1450652021. View Article : Google Scholar | |
van Zonneveld AJ, Kölling M, Bijkerk R and Lorenzen JM: Circular RNAs in kidney disease and cancer. Nat Rev Nephrol. 17:814–826. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lasda E and Parker R: Circular RNAs: Diversity of form and function. RNA. 20:1829–1842. 2014. View Article : Google Scholar : PubMed/NCBI | |
Petkovic S and Müller S: RNA circularization strategies in vivo and in vitro. Nucleic Acids Res. 43:2454–2465. 2015. View Article : Google Scholar : PubMed/NCBI | |
Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E and Masuda S: The Closely Related RNA helicases, UAP56 and URH49, Preferentially Form Distinct mRNA Export Machineries and Coordinately Regulate Mitotic Progression. Mol Biol Cell. 21:2953–2965. 2010. View Article : Google Scholar : PubMed/NCBI | |
Huang C, Liang D, Tatomer DC and Wilusz JE: A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev. 32:639–644. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ren L, Jiang Q, Mo L, Tan L, Dong Q, Meng L, Yang N and Li G: Mechanisms of circular RNA degradation. Commun Biol. 5:13552022. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Huang S, Zhuang H, Ruan S, Zhou Z, Huang K, Ji F, Ma Z, Hou B and He X: YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation. Oncogene. 39:4507–4518. 2020. View Article : Google Scholar : PubMed/NCBI | |
Chang W and Wang J: Exosomes and their noncoding RNA cargo are emerging as new modulators for diabetes mellitus. Cells. 8:8532019. View Article : Google Scholar : PubMed/NCBI | |
Hentze MW and Preiss T: Circular RNAs: Splicing's enigma variations. EMBO J. 32:923–925. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Liu J, Ma J, Sun T, Zhou Q, Wang W, Wang G, Wu P, Wang H, Jiang L, et al: Exosomal circRNAs: Biogenesis, effect and application in human diseases. Mol Cancer. 18:1162019. View Article : Google Scholar : PubMed/NCBI | |
Chen XT, Li ZW, Zhao X, Li ML, Hou PF, Chu SF, Zheng JN and Bai J: Role of Circular RNA in kidney-related diseases. Front Pharmacol. 12:6158822021. View Article : Google Scholar : PubMed/NCBI | |
Wang H, Gao X, Yu S, Wang W, Liu G, Jiang X and Sun D: Circular RNAs regulate parental gene expression: A new direction for molecular oncology research. Front Oncol. 12:9477752022. View Article : Google Scholar : PubMed/NCBI | |
Wu N, Yuan Z, Du KY, Fang L, Lyu J, Zhang C, He A, Eshaghi E, Zeng K, Ma J, et al: Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery. Cell Death Differ. 26:2758–2773. 2019. View Article : Google Scholar : PubMed/NCBI | |
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, et al: Circ-ZNF609 Is a Circular RNA that Can Be translated and functions in myogenesis. Mol Cell. 66:22–37.e9. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhang Z, Yang T and Xiao J: Circular RNAs: Promising biomarkers for human diseases. EBioMedicine. 34:267–274. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: CircRNA Biogenesis competes with Pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI | |
Du WW, Yang W, Liu E, Yang Z, Dhaliwal P and Yang BB: Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 44:2846–2858. 2016. View Article : Google Scholar : PubMed/NCBI | |
Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J and Bindereif A: CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Sci Rep. 6:313132016. View Article : Google Scholar : PubMed/NCBI | |
Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, et al: Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Commun. 7:124292016. View Article : Google Scholar : PubMed/NCBI | |
Das A, Sinha T, Shyamal S and Panda AC: Emerging role of circular RNA-protein interactions. Noncoding RNA. 7:482021.PubMed/NCBI | |
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, et al: Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. Cell. 149:1393–1406. 2012. View Article : Google Scholar : PubMed/NCBI | |
Yar Saglam SA, Alp E and Ilke Onen H: Circular RNAs and its biological functions in health and disease. Gene Expression and Phenotypic Traits. Chen YC and Chen SJ: IntechOpen; pp. 1–37. 2020 | |
Yang Q, Li F, He AT and Yang BB: Circular RNAs: Expression, localization, and therapeutic potentials. Mol Ther. 29:1683–1702. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Lu T, Wang Q, Liu J and Jiao W: Circular RNAs: Crucial regulators in the human body (Review). Oncol Rep. 40:3119–3135. 2018.PubMed/NCBI | |
Wang M, Yu F, Wu W, Zhang Y, Chang W, Ponnusamy M, Wang K and Li P: Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity. Int J Biol Sci. 13:1497–1506. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yang L, Fu J and Zhou Y: Circular RNAs and their emerging roles in immune regulation. Front Immunol. 9:29772018. View Article : Google Scholar | |
Shao T, Pan YH and Xiong XD: Circular RNA: an important player with multiple facets to regulate its parental gene expression. Mol Ther Nucleic Acids. 23:369–376. 2020. View Article : Google Scholar | |
Chen N, Zhao G, Yan X, Lv Z, Yin H, Zhang S, Song W, Li X, Li L, Du Z, et al: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1. Genome Biol. 19:2182018. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Song J, Liu Y, Zhou Z and Wang X: Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2. J Exp Clin Cancer Res. 39:1012020. View Article : Google Scholar : PubMed/NCBI | |
Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L and Pedersen JS: Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. NPJ Genom Med. 2:362017. View Article : Google Scholar : PubMed/NCBI | |
Selby NM and Taal MW: An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 22(Suppl 1): S3–S15. 2020. View Article : Google Scholar | |
Gheith O, Farouk N, Nampoory N, Halim MA and Al-Otaibi T: Diabetic kidney disease: Worldwide difference of prevalence and risk factors. J Nephropharmacol. 5:49–56. 2015.eCollection 2016. | |
Brosius FC, Khoury CC, Buller CL and Chen S: Abnormalities in signaling pathways in diabetic nephropathy. Expert Rev Endocrinol Metab. 5:51–64. 2010. View Article : Google Scholar : PubMed/NCBI | |
Cooper ME: Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia. 44:1957–1972. 2001. View Article : Google Scholar : PubMed/NCBI | |
Makita Z, Radoff S, Rayfield EJ, Yang Z, Skolnik E, Delaney V, Friedman EA, Cerami A and Vlassara H: Advanced glycosylation end products in patients with diabetic nephropathy. N Engl J Med. 325:836–842. 1991. View Article : Google Scholar : PubMed/NCBI | |
Busch M, Franke S, Rüster C and Wolf G: Advanced glycation end-products and the kidney. Eur J Clin Invest. 40:742–755. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ramasamy R, Yan SF and Schmidt AM: Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci. 1243:88–102. 2011. View Article : Google Scholar | |
Kay AM, Simpson CL and Stewart JA Jr: The role of AGE/RAGE signaling in diabetes-mediated vascular calcification. J Diabetes Res. 2016:68097032016. View Article : Google Scholar : PubMed/NCBI | |
Yun J, Ren J, Liu Y, Dai L, Song L, Ma X, Luo S and Song Y: Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy. Diabetol Metab Syndr. 13:722021. View Article : Google Scholar : PubMed/NCBI | |
Wang Q, Cang Z, Shen L, Peng W, Xi L, Jiang X, Ge X, Xu B and Huang S: circ_0037128/miR-17-3p/AKT3 axis promotes the development of diabetic nephropathy. Gene. 765:1450762021. View Article : Google Scholar | |
Feng T, Li W, Li T, Jiao W and Chen S: Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis. Bioengineered. 12:10959–10970. 2021. View Article : Google Scholar : PubMed/NCBI | |
Fang R, Cao X, Zhu Y and Chen Q: Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9. Autoimmunity. 55:254–263. 2022. View Article : Google Scholar : PubMed/NCBI | |
Tang B, Li W, Ji TT, Li XY, Qu X, Feng L and Bai S: Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals. J Cell Mol Med. 24:8779–8788. 2020. View Article : Google Scholar : PubMed/NCBI | |
Hu W, Han Q, Zhao L and Wang L: Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-β1. J Cell Physiol. 234:1469–1476. 2019. View Article : Google Scholar | |
Mou X, Chen JW, Zhou DY, Liu K, Chen LJ, Zhou D and Hu YB: A novel identified circular RNA, circ-0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR-101b by targeting TGFβRI. Mol Med Rep. 22:3785–3794. 2020.PubMed/NCBI | |
Bai S, Xiong X, Tang B, Ji T, Li X, Qu X and Li W: Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-κB/MMP-2 axis. Cell Death Dis. 11:10082020. View Article : Google Scholar | |
Xu B, Wang Q, Li W, Xia L, Ge X, Shen L, Cang Z, Peng W, Shao K and Huang S: Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218. J Cell Mol Med. 26:1799–1805. 2022. View Article : Google Scholar | |
Yao T, Zha D, Hu C and Wu X: Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy. Gene. 747:1446612020. View Article : Google Scholar : PubMed/NCBI | |
Qiu B, Qi X and Wang J: CircTLK1 downregulation attenuates high glucose-induced human mesangial cell injury by blocking the AKT/NF-κB pathway through sponging miR-126-5p/miR-204-5p. Biochem Genet. 60:1471–1487. 2022. View Article : Google Scholar | |
Chen B, Li Y, Liu Y and Xu Z: circLRP6 regulates high glucose-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells. J Cell Physiol. 234:21249–21259. 2019. View Article : Google Scholar : PubMed/NCBI | |
Feng F, Yang J, Wang G, Huang P, Li Y and Zhou B: Circ_0068087 promotes high glucose-induced human renal tubular cell injury through regulating miR-106a-5p/ROCK2 pathway. Nephron. 147:212–222. 2023. View Article : Google Scholar | |
Zhuang L, Wang Z, Hu X, Yang Q, Pei X and Jin G: CircHIPK3 alleviates high glucose toxicity to human renal tubular epithelial HK-2 cells through regulation of miR-326/miR-487a-3p/SIRT1. Diabetes Metab Syndr Obes. 14:729–740. 2021. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Wang X, Wang ZY and Li L: Circ_0080425 inhibits cell proliferation and fibrosis in diabetic nephropathy via sponging miR-24-3p and targeting fibroblast growth factor 11. J Cell Physiol. 235:4520–4529. 2020. View Article : Google Scholar | |
Wang W, Feng J, Zhou H and Li Q: Circ_0123996 promotes cell proliferation and fibrosis in mouse mesangial cells through sponging miR-149-5p and inducing Bach1 expression. Gene. 761:1449712020. View Article : Google Scholar | |
Li G, Qin Y, Qin S, Zhou X, Zhao W and Zhang D: Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells. Life Sci. 259:1182692020. View Article : Google Scholar : PubMed/NCBI | |
An L, Ji D, Hu W, Wang J, Jin X, Qu Y and Zhang N: Interference of hsa_circ_0003928 alleviates high glucose-induced cell apoptosis and inflammation in HK-2 cells via mir-151-3p/anxa2. Diabetes Metab Syndr Obes. 13:3157–3168. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu Q, Cui Y, Ding N and Zhou C: Knockdown of circ_0003928 ameliorates high glucose-induced dysfunction of human tubular epithelial cells through the miR-506-3p/HDAC4 pathway in diabetic nephropathy. Eur J Med Res. 27:552022. View Article : Google Scholar : PubMed/NCBI | |
Ge X, Xi L, Wang Q, Li H, Xia L, Cang Z, Peng W and Huang S: Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy. Gene. 758:1449522020. View Article : Google Scholar : PubMed/NCBI | |
Sun L, Han Y, Shen C, Luo H and Wang Z: Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis. J Recept Signal Transduct Res. 42:302–312. 2022. View Article : Google Scholar | |
Wang H, Huang S, Hu T, Fei S and Zhang H: Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis. BMC Endocr Disord. 22:672022. View Article : Google Scholar : PubMed/NCBI | |
Li J, Min Y and Zhao Q: Circ_0000064 knockdown attenuates high glucose-induced proliferation, inflammation and extracellular matrix deposition of mesangial cells through miR-424-5p-mediated WNT2B inhibition in cell models of diabetic nephropathy. Clin Exp Nephrol. 26:943–954. 2022. View Article : Google Scholar : PubMed/NCBI | |
Peng F, Gong W, Li S, Yin B, Zhao C, Liu W, Chen X, Luo C, Huang Q, Chen T, et al: circRNA_010383 Acts as a Sponge for miR-135a, and its downregulated expression contributes to renal fibrosis in diabetic nephropathy. Diabetes. 70:603–615. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Qi Y, Ji T, Tang B, Li X, Zheng P and Bai S: Circ_LARP4 regulates high glucose-induced cell proliferation, apoptosis, and fibrosis in mouse mesangial cells. Gene. 765:1451142021. View Article : Google Scholar | |
Sun A, Sun N, Liang X and Hou Z: Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B. Diabetol Metab Syndr. 13:1412021. View Article : Google Scholar : PubMed/NCBI | |
Wu R, Niu Z, Ren G, Ruan L and Sun L: CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition. Diabetol Metab Syndr. 13:1372021. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Duan P, Xu C, Xu D, Liu Y and Jiang J: CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis. Inflamm Res. 70:835–846. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhao L, Chen H, Zeng Y, Yang K, Zhang R, Li Z, Yang T and Ruan H: Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis. Endocr J. 68:1155–1164. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhu Y, Zha F, Tang B, Ji TT, Li XY, Feng L and Bai SJ: Exosomal hsa_circ_0125310 promotes cell proliferation and fibrosis in diabetic nephropathy via sponging miR-422a and targeting the IGF1R/p38 axis. J Cell Mol Med. 26:151–162. 2022. View Article : Google Scholar | |
Jin J, Wang Y, Zheng D, Liang M and He Q: A Novel Identified Circular RNA, mmu_mmu_circRNA_0000309, Involves in Germacrone-Mediated Improvement of Diabetic Nephropathy Through Regulating Ferroptosis by Targeting miR-188-3p/GPX4 Signaling Axis. Antioxid Redox Signal. 36:740–759. 2022. View Article : Google Scholar | |
Chen S: Circ_000166/miR-296 aggravates the process of diabetic renal fibrosis by regulating the SGLT2 signaling pathway in renal tubular epithelial cells. Dis Markers. 2022:61030862022.PubMed/NCBI | |
Wang D, Zhang Z, Si Z and Wang L: Circ 0006282/miR-155 reduced inflammation in diabetic nephropathy via expression of SIRT1/NLRP3 signaling pathway. Food Sci Technol (Campinas). 42:e395202022. View Article : Google Scholar | |
Li Y, Yu W, Xiong H and Yuan F: Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy. Sci Rep. 12:119942022. View Article : Google Scholar : PubMed/NCBI | |
Zhuang L, Jin G, Qiong W, Ge X and Pei X: Circular RNA COL1A2 mediates high glucose-induced oxidative stress and pyroptosis by regulating MiR-424-5p/SGK1 in diabetic nephropathy. Appl Biochem Biotechnol. 195:7652–7667. 2023. View Article : Google Scholar : PubMed/NCBI | |
Liu X and Wu Y: Circ_0000953 deficiency exacerbates podocyte injury and autophage through targeting mir-655/atg4b in diabetic nephropathy. Kidney Int Rep. 8:S198–S199. 2023. View Article : Google Scholar | |
Rashad NM, Sherif MH, El-Shal AS and Abdelsamad MAE: The expression profile of circANKRD36 and ANKRD36 as diagnostic biomarkers of chronic kidney disease in patients with type 2 diabetes mellitus. Egypt J Med Hum Genet. 22:432021. View Article : Google Scholar | |
Zhang K, Wan X, Khan MA, Sun X, Yi X, Wang Z, Chen K and Peng L: Peripheral Blood circRNA microarray profiling identities hsa_circ_0001831 and hsa_circ_0000867 as two novel circrna biomarkers for early type 2 diabetic nephropathy. Diabetes Metab Syndr Obes. 15:2789–2801. 2022. View Article : Google Scholar : PubMed/NCBI | |
Badr AM, Elkholy O, Said M, Fahim SA, El-Khatib M, Sabry D and Gaber RM: Diagnostic Significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for diabetic kidney disease in patients with type 2 diabetes mellitus. J Med Biochem. 42:239–248. 2023. View Article : Google Scholar : PubMed/NCBI | |
Ling L, Tan Z, Zhang C, Gui S, Cui Y, Hu Y and Chen L: CircRNAs in exosomes from high glucose-treated glomerular endothelial cells activate mesangial cells. Am J Transl Res. 11:4667–4682. 2019.PubMed/NCBI | |
Liu M and Zhao J: Circular RNAs in diabetic nephropathy: Updates and perspectives. Aging Dis. 13:1365–1380. 2022. View Article : Google Scholar : PubMed/NCBI | |
Loganathan TS, Sulaiman SA, Abdul Murad NA, Shah SA, Abdul Gafor AH, Jamal R and Abdullah N: Interactions Among Non-Coding RNAs in Diabetic Nephropathy. Front Pharmacol. 11:1912020. View Article : Google Scholar : PubMed/NCBI | |
Xiong X, Liu C, Shen M, Yang Q, Zhao Q, Li X, Zhong X and Wang Z: Circular RNA expression profile in transgenic diabetic mouse kidneys. Cell Mol Biol Lett. 26:252021. View Article : Google Scholar : PubMed/NCBI | |
Bai YH, Wang JP, Yang M, Zeng Y and Jiang HY: SiRNA-HMGA2 weakened AGEs-induced epithelial-to-mesenchymal transition in tubular epithelial cells. Biochem Biophys Res Commun. 457:730–735. 2015. View Article : Google Scholar : PubMed/NCBI | |
Birchmeier W and Behrens J: Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1198:11–26. 1994.PubMed/NCBI | |
Li JH, Wang W, Huang XR, Oldfield M, Schmidt AM, Cooper ME and Lan HY: Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway. Am J Pathol. 164:1389–1397. 2004. View Article : Google Scholar : PubMed/NCBI | |
Guria A, Sharma P, Natesan S and Pandi G: Circular RNAs-The road less traveled. Front Mol Biosci. 6:1462020. View Article : Google Scholar : PubMed/NCBI | |
Ikeda Y, Morikawa S, Nakashima M, Yoshikawa S, Taniguchi K, Sawamura H, Suga N, Tsuji A and Matsuda S: CircRNAs and RNA-Binding proteins involved in the pathogenesis of cancers or central nervous system disorders. Noncoding RNA. 9:232023.PubMed/NCBI | |
Zeng Y, Du WW, Wu Y, Yang Z, Awan FM, Li X, Yang W, Zhang C, Yang Q, Yee A, et al: A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Theranostics. 7:3842–3855. 2017. View Article : Google Scholar : PubMed/NCBI | |
Stoll L, Rodríguez-Trejo A, Guay C, Brozzi F, Bayazit MB, Gattesco S, Menoud V, Sobel J, Marques AC, Venø MT, et al: A circular RNA generated from an intron of the insulin gene controls insulin secretion. Nat Commun. 11:56112020. View Article : Google Scholar : PubMed/NCBI | |
Hou L, Wei Y, Lin Y, Wang X, Lai Y, Yin M, Chen Y, Guo X, Wu S, Zhu Y, et al: Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Res. 48:3869–3887. 2020. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Han X, Yang L, Fu J, Sun C, Huang S, Xiao W, Gao Y, Liang Q, Wang X, et al: Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. Theranostics. 10:10908–10924. 2020. View Article : Google Scholar : PubMed/NCBI | |
Livi CM, Klus P, Delli Ponti R and Tartaglia GG: CatRAPID signature: Identification of ribonucleoproteins and RNA-binding regions. Bioinformatics. 32:773–775. 2016. View Article : Google Scholar : | |
Bailey TL, Johnson J, Grant CE and Noble WS: The MEME Suite. Nucleic Acids Res. 43(W1): W39–W49. 2015. View Article : Google Scholar : PubMed/NCBI | |
Gupta S, Stamatoyannopoulos JA, Bailey TL and Noble WS: Quantifying similarity between motifs. Genome Biol. 8:R242007. View Article : Google Scholar : PubMed/NCBI | |
Muppirala UK, Honavar VG and Dobbs D: Predicting RNA-Protein interactions using only sequence information. BMC Bioinformatics. 12:4892011. View Article : Google Scholar : PubMed/NCBI | |
Pan X, Fang Y, Li X, Yang Y and Shen HB: RBPsuite: RNA-protein binding sites prediction suite based on deep learning. BMC Genomics. 21:8842020. View Article : Google Scholar : PubMed/NCBI | |
Lin YC, Boone M, Meuris L, Lemmens I, Van Roy N, Soete A, Reumers J, Moisse M, Plaisance S, Drmanac R, et al: Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations. Nat Commun. 5:47672014. View Article : Google Scholar : PubMed/NCBI | |
Zhou WY, Cai ZR, Liu J, Wang DS, Ju HQ and Xu RH: Circular RNA: Metabolism, functions and interactions with proteins. Mol Cancer. 19:1722020. View Article : Google Scholar : PubMed/NCBI | |
Kreisberg JI, Radnik RA, Ayo SH, Garoni J and Saikumar P: High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures. Kidney Int. 46:105–112. 1994. View Article : Google Scholar : PubMed/NCBI | |
Xu YX, Pu SD, Li X, Yu ZW, Zhang YT, Tong XW, Shan YY and Gao XY: Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications. Pharmacol Res. 178:1061352022. View Article : Google Scholar : PubMed/NCBI | |
Feng S, LV L, Liu B, Zhu X and Jing J: MO619: Landscape RNA Profiling of Urinary Extracellular Vesicles in Patients with Diabetic Nephropathy. Nephrology Dialysis Transplantation. 37:2022. View Article : Google Scholar | |
Sinha N, Kumar V, Puri V, Nada R, Rastogi A, Jha V and Puri S: Urinary exosomes: Potential biomarkers for diabetic nephropathy. Nephrology (Carlton). 25:881–887. 2020. View Article : Google Scholar : PubMed/NCBI | |
Xie Y, Jia Y, Cuihua X, Hu F, Xue M and Xue Y: Urinary exosomal MicroRNA profiling in incipient type 2 diabetic kidney disease. J Diabetes Res. 2017:69789842017. View Article : Google Scholar : PubMed/NCBI | |
Zhao Y, Shen A, Guo F, Song Y, Jing N, Ding X, Pan M, Zhang H, Wang J, Wu L, et al: Urinary Exosomal MiRNA-4534 as a novel diagnostic biomarker for diabetic kidney disease. Front Endocrinol (Lausanne). 11:5902020. View Article : Google Scholar : PubMed/NCBI | |
Cao Y, Shi Y, Yang Y, Wu Z, Peng N, Xiao J, Dou F, Xu J, Pei W, Fu C, et al: Urinary exosomes derived circRNAs as biomarkers for chronic renal fibrosis. Ann Med. 54:1966–1976. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ma H, Xu Y, Zhang R, Guo B, Zhang S and Zhang X: Differential expression study of circular RNAs in exosomes from serum and urine in patients with idiopathic membranous nephropathy. Arch Med Sci. 15:738–753. 2019. View Article : Google Scholar : PubMed/NCBI | |
Luan R, Tian G, Ci X, Zheng Q, Wu L and Lu X: Differential expression analysis of urinary exosomal circular RNAs in patients with IgA nephropathy. Nephrology (Carlton). 26:432–441. 2021. View Article : Google Scholar : PubMed/NCBI |