Open Access

PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review)

  • Authors:
    • Xinyu Gao
    • Cuixue Ma
    • Shan Liang
    • Meihong Chen
    • Yuan He
    • Wei Lei
  • View Affiliations

  • Published online on: July 4, 2024     https://doi.org/10.3892/ijmm.2024.5398
  • Article Number: 74
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that has been widely reported in cancer, infectious diseases and neurological disorders. Cardiovascular diseases (CVDs) are an important global health problem, posing a serious threat to individuals' lives. An increasing body of research shows that inflammation has a pivotal role in CVDs, which provides an important theoretical basis for PANoptosis to promote the progression of CVDs. To date, only sporadic studies on PANoptosis in CVDs have been reported and its role in the field of CVDs has not been fully explored. Elucidating the various modes of cardiomyocyte death, the specific molecular mechanisms and the links among the various modes of death under various stressful stimuli is of notable clinical significance for a deeper understanding of the pathophysiology of CVDs. The present review summarizes the molecular mechanisms of apoptosis, pyroptosis, necroptosis and PANoptosis and their prospects in the field of CVDs.
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September-2024
Volume 54 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Gao X, Ma C, Liang S, Chen M, He Y and Lei W: PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review). Int J Mol Med 54: 74, 2024.
APA
Gao, X., Ma, C., Liang, S., Chen, M., He, Y., & Lei, W. (2024). PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review). International Journal of Molecular Medicine, 54, 74. https://doi.org/10.3892/ijmm.2024.5398
MLA
Gao, X., Ma, C., Liang, S., Chen, M., He, Y., Lei, W."PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review)". International Journal of Molecular Medicine 54.3 (2024): 74.
Chicago
Gao, X., Ma, C., Liang, S., Chen, M., He, Y., Lei, W."PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review)". International Journal of Molecular Medicine 54, no. 3 (2024): 74. https://doi.org/10.3892/ijmm.2024.5398