Open Access

Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis

  • Authors:
    • Bohan Zeng
    • Runlan Wan
    • Kun Chang
    • Jing Li
    • Xuanzhi Zhang
    • Guohai Shi
    • Dingwei Ye
    • Fujiang Xu
  • View Affiliations

  • Published online on: March 1, 2024     https://doi.org/10.3892/ijo.2024.5633
  • Article Number: 45
  • Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Among all types of renal cancer, clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype and is associated with a high risk of metastasis and recurrence. Histone modifications regulate several biological processes that are fundamental to the development of cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) is an epigenetic modifier responsible for the trimethylation of H4K20, which drives critical cellular events, including genome integrity, cell growth and epithelial‑mesenchymal transition (EMT), in various types of cancer. However, the role of KMT5C in ccRCC remains unclear. As such, the expression and function of KMT5C in ccRCC were investigated in the present study. KMT5C expression was significantly increased in ccRCC tissues compared with normal tissues (P<0.0001), and it was closely associated with the overall survival rate of patients with ccRCC. By establishing ccRCC cell lines with KMT5C expression knockdown, the role of KMT5C in the maintenance of aerobic glycolysis in ccRCC cells via the regulation of several vital glycolytic genes was identified. Additionally, KMT5C promoted the proliferation and EMT of ccRCC cells by controlling crucial EMT transcriptional factors. Together, these data suggested that KMT5C may act as an oncoprotein, guide molecular diagnosis, and shed light on novel drug development and therapeutic strategies for patients with ccRCC.
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April-2024
Volume 64 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zeng B, Wan R, Chang K, Li J, Zhang X, Shi G, Ye D and Xu F: Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis. Int J Oncol 64: 45, 2024.
APA
Zeng, B., Wan, R., Chang, K., Li, J., Zhang, X., Shi, G. ... Xu, F. (2024). Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis. International Journal of Oncology, 64, 45. https://doi.org/10.3892/ijo.2024.5633
MLA
Zeng, B., Wan, R., Chang, K., Li, J., Zhang, X., Shi, G., Ye, D., Xu, F."Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis". International Journal of Oncology 64.4 (2024): 45.
Chicago
Zeng, B., Wan, R., Chang, K., Li, J., Zhang, X., Shi, G., Ye, D., Xu, F."Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis". International Journal of Oncology 64, no. 4 (2024): 45. https://doi.org/10.3892/ijo.2024.5633