Open Access

Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review)

  • Authors:
    • Carlos Jiménez‑Cortegana
    • Cristian Gutiérrez‑García
    • Flora Sánchez‑Jiménez
    • Teresa Vilariño‑García
    • Rocio Flores‑Campos
    • Antonio Pérez‑Pérez
    • Carmen Garnacho
    • Maria L. Sánchez‑León
    • Daniel J. García‑Domínguez
    • Lourdes Hontecillas‑Prieto
    • Natalia Palazón‑Carrión
    • Luis De La Cruz‑Merino
    • Víctor Sánchez‑Margalet
  • View Affiliations

  • Published online on: June 27, 2024     https://doi.org/10.3892/ijo.2024.5667
  • Article Number: 79
  • Copyright: © Jiménez‑Cortegana et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Obesity is a chronic disease caused by the accumulation of excessive adipose tissue. This disorder is characterized by chronic low‑grade inflammation, which promotes the release of proinflammatory mediators, including cytokines, chemokines and leptin. Simultaneously, chronic inflammation can predispose to cancer development, progression and metastasis. Proinflammatory molecules are involved in the recruitment of specific cell populations in the tumor microenvironment. These cell populations include myeloid‑derived suppressor cells (MDSCs), a heterogeneous, immature myeloid population with immunosuppressive abilities. Obesity‑associated MDSCs have been linked with tumor dissemination, progression and poor clinical outcomes. A comprehensive literature review was conducted to assess the impact of obesity‑associated MDSCs on cancer in both preclinical models and oncological patients with obesity. A secondary objective was to examine the key role that leptin, the most important proinflammatory mediator released by adipocytes, plays in MDSC‑driven immunosuppression Finally, an overview is provided of the different therapeutic approaches available to target MDSCs in the context of obesity‑related cancer.
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August-2024
Volume 65 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Jiménez‑Cortegana C, Gutiérrez‑García C, Sánchez‑Jiménez F, Vilariño‑García T, Flores‑Campos R, Pérez‑Pérez A, Garnacho C, Sánchez‑León ML, García‑Domínguez DJ, Hontecillas‑Prieto L, Hontecillas‑Prieto L, et al: Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review). Int J Oncol 65: 79, 2024.
APA
Jiménez‑Cortegana, C., Gutiérrez‑García, C., Sánchez‑Jiménez, F., Vilariño‑García, T., Flores‑Campos, R., Pérez‑Pérez, A. ... Sánchez‑Margalet, V. (2024). Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review). International Journal of Oncology, 65, 79. https://doi.org/10.3892/ijo.2024.5667
MLA
Jiménez‑Cortegana, C., Gutiérrez‑García, C., Sánchez‑Jiménez, F., Vilariño‑García, T., Flores‑Campos, R., Pérez‑Pérez, A., Garnacho, C., Sánchez‑León, M. L., García‑Domínguez, D. J., Hontecillas‑Prieto, L., Palazón‑Carrión, N., De La Cruz‑Merino, L., Sánchez‑Margalet, V."Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review)". International Journal of Oncology 65.2 (2024): 79.
Chicago
Jiménez‑Cortegana, C., Gutiérrez‑García, C., Sánchez‑Jiménez, F., Vilariño‑García, T., Flores‑Campos, R., Pérez‑Pérez, A., Garnacho, C., Sánchez‑León, M. L., García‑Domínguez, D. J., Hontecillas‑Prieto, L., Palazón‑Carrión, N., De La Cruz‑Merino, L., Sánchez‑Margalet, V."Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review)". International Journal of Oncology 65, no. 2 (2024): 79. https://doi.org/10.3892/ijo.2024.5667