Open Access

Effect of Paullinia cupana on MCF‑7 breast cancer cell response to chemotherapeutic drugs

  • Authors:
    • Everaldo Hertz
    • Francine Carla Cadoná
    • Alencar Kolinski Machado
    • Verônica Azzolin
    • Sabrina Holmrich
    • Charles Assmann
    • Pauline Ledur
    • Euler Esteves Ribeiro
    • Olmiro Cezimbra de Souza Filho
    • Maria Fernanda Mânica‑Cattani
    • Ivana Beatrice Mânica da Cruz
  • View Affiliations

  • Published online on: October 8, 2014     https://doi.org/10.3892/mco.2014.438
  • Pages: 37-43
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Abstract

Previous studies suggested that certain plants, such as guarana (Paullinia cupana), exert a protective effect against cancer‑related fatigue in breast cancer patients undergoing chemotherapy. However, guarana possesses bioactive molecules, such as caffeine and catechin, which may affect the pharmacological properties of antitumor drugs. Therefore, the aim of this study was to evaluate the effects of guarana on breast cancer cell response to 7 chemotherapeutic agents currently used in the treatment of breast cancer. To perform this study, MCF‑7 breast cancer cells were cultured under controlled conditions and exposed to 1, 5 and 10 µg/ml guarana concentrations, with and without chemotherapeutics (gemcitabine, vinorelbine, methotrexate, 5‑fluorouracil, paclitaxel, doxorubicin and cyclophosphamide). The effect of these treatments on MCF‑7 cell viability and proliferation was spectrophotometrically analyzed with the MTT assay. The main results demonstrated an antiproliferative effect of guarana at concentrations of 5 and 10 µg/ml and a significant effect on chemotherapeutic drug action. In general, guarana improved the antiproliferative effect of chemotherapeutic agents, causing a decrease of >40% in cell growth after 72 h of exposure. The results suggested an interaction of guarana with the chemotherapeutic drugs, which requires confirmation by in vivo complementary studies.
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January-February 2015
Volume 3 Issue 1

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Spandidos Publications style
Hertz E, Cadoná FC, Machado AK, Azzolin V, Holmrich S, Assmann C, Ledur P, Ribeiro EE, de Souza Filho OC, Mânica‑Cattani MF, Mânica‑Cattani MF, et al: Effect of Paullinia cupana on MCF‑7 breast cancer cell response to chemotherapeutic drugs. Mol Clin Oncol 3: 37-43, 2015.
APA
Hertz, E., Cadoná, F.C., Machado, A.K., Azzolin, V., Holmrich, S., Assmann, C. ... da Cruz, I.B. (2015). Effect of Paullinia cupana on MCF‑7 breast cancer cell response to chemotherapeutic drugs. Molecular and Clinical Oncology, 3, 37-43. https://doi.org/10.3892/mco.2014.438
MLA
Hertz, E., Cadoná, F. C., Machado, A. K., Azzolin, V., Holmrich, S., Assmann, C., Ledur, P., Ribeiro, E. E., de Souza Filho, O. C., Mânica‑Cattani, M. F., da Cruz, I. B."Effect of Paullinia cupana on MCF‑7 breast cancer cell response to chemotherapeutic drugs". Molecular and Clinical Oncology 3.1 (2015): 37-43.
Chicago
Hertz, E., Cadoná, F. C., Machado, A. K., Azzolin, V., Holmrich, S., Assmann, C., Ledur, P., Ribeiro, E. E., de Souza Filho, O. C., Mânica‑Cattani, M. F., da Cruz, I. B."Effect of Paullinia cupana on MCF‑7 breast cancer cell response to chemotherapeutic drugs". Molecular and Clinical Oncology 3, no. 1 (2015): 37-43. https://doi.org/10.3892/mco.2014.438