Adenovirus type 3 induces platelet activation in vitro

  • Authors:
    • Ying-Yu Jin
    • Xiu-Nan Yu
    • Zhang-Yi Qu
    • Ai-Ai Zhang
    • Yu‑Ling  Xing
    • Li-Xin Jiang
    • Lei Shang
    • Ying-Chen Wang
  • View Affiliations

  • Published online on: November 15, 2013     https://doi.org/10.3892/mmr.2013.1805
  • Pages: 370-374
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Abstract

In the present study, we aimed to investigate platelet activation induced by adenovirus type 3 (HAdV3) in vitro. Platelet-rich plasma (PRP) or whole blood was incubated with or without HAdV at various concentrations. Platelet aggregation, platelet counting, fibrinogen and expression of platelet membrane antigens (CD41a and CD62P) were determined following incubation with HAdV for different periods of time. The results demonstrated that HAdV at the concentrations of 109-1011 vp/ml enhanced adenosine diphosphate (ADP) or ristocetin-induced platelet aggregation, however did not alter the platelet count. Infection with HAdVs also reduced fibrinogen level. P-selectin and CD41a appeared rapidly on the surface after platelets were incubated with HAdVs in vitro for 30 min. In conclusion, HAdVs may induce activation of platelets and lead to a pre-thrombotic state of peripheral blood. This finding may aid in the development of measures to prevent severe HAdV infection.
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2014-January
Volume 9 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Jin Y, Yu X, Qu Z, Zhang A, Xing YL, Jiang L, Shang L and Wang Y: Adenovirus type 3 induces platelet activation in vitro. Mol Med Rep 9: 370-374, 2014.
APA
Jin, Y., Yu, X., Qu, Z., Zhang, A., Xing, Y., Jiang, L. ... Wang, Y. (2014). Adenovirus type 3 induces platelet activation in vitro. Molecular Medicine Reports, 9, 370-374. https://doi.org/10.3892/mmr.2013.1805
MLA
Jin, Y., Yu, X., Qu, Z., Zhang, A., Xing, Y., Jiang, L., Shang, L., Wang, Y."Adenovirus type 3 induces platelet activation in vitro". Molecular Medicine Reports 9.1 (2014): 370-374.
Chicago
Jin, Y., Yu, X., Qu, Z., Zhang, A., Xing, Y., Jiang, L., Shang, L., Wang, Y."Adenovirus type 3 induces platelet activation in vitro". Molecular Medicine Reports 9, no. 1 (2014): 370-374. https://doi.org/10.3892/mmr.2013.1805