Open Access

The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)

  • Authors:
    • Kuo Yan
    • Li‑Na Gao
    • Yuan‑Lu Cui
    • Yi Zhang
    • Xin Zhou
  • View Affiliations

  • Published online on: March 18, 2016     https://doi.org/10.3892/mmr.2016.5005
  • Pages: 3715-3723
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

During development of disease, complex intracellular signaling pathways regulate an intricate series of events, including resistance to external toxins, the secretion of cytokines and the production of pathological phenomena. Adenosine 3',5'-cyclic monophosphate (cAMP) is a nucleotide that acts as a key second messenger in numerous signal transduction pathways. cAMP regulates various cellular functions, including cell growth and differentiation, gene transcription and protein expression. This review aimed to provide an understanding of the effects of the cAMP signaling pathway and the associated factors on disease occurrence and development by examining the information from a new perspective. These novel insights aimed to promote the development of novel therapeutic approaches and aid in the development of new drugs.
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May-2016
Volume 13 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yan K, Gao LN, Cui YL, Zhang Y and Zhou X: The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review). Mol Med Rep 13: 3715-3723, 2016.
APA
Yan, K., Gao, L., Cui, Y., Zhang, Y., & Zhou, X. (2016). The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review). Molecular Medicine Reports, 13, 3715-3723. https://doi.org/10.3892/mmr.2016.5005
MLA
Yan, K., Gao, L., Cui, Y., Zhang, Y., Zhou, X."The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)". Molecular Medicine Reports 13.5 (2016): 3715-3723.
Chicago
Yan, K., Gao, L., Cui, Y., Zhang, Y., Zhou, X."The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)". Molecular Medicine Reports 13, no. 5 (2016): 3715-3723. https://doi.org/10.3892/mmr.2016.5005