Open Access

Mangiferin: An effective therapeutic agent against several disorders (Review)

  • Authors:
    • Suya Du
    • Huirong Liu
    • Tiantian Lei
    • Xiaofang Xie
    • Hailian Wang
    • Xia He
    • Rongsheng Tong
    • Yi Wang
  • View Affiliations

  • Published online on: October 2, 2018     https://doi.org/10.3892/mmr.2018.9529
  • Pages: 4775-4786
  • Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mangiferin (1,3,6,7‑tetrahydroxyxanthone‑C2‑β‑D‑glucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, anti‑hyperuricemic, neuroprotective, antioxidant, anti‑inflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several health‑endorsing properties and is a promising candidate for further research and development. However, low solubility, mucosal permeability and bioavailability restrict the development of mangiferin as a clinical therapeutic, and chemical and physical modification is required to expand its application. This review comprehensively analyzed and collectively summarized the primary pharmacological actions of mangiferin that have been demonstrated in the literature, to support the potential future development of mangiferin as a novel therapeutic drug.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Du S, Liu H, Lei T, Xie X, Wang H, He X, Tong R and Wang Y: Mangiferin: An effective therapeutic agent against several disorders (Review). Mol Med Rep 18: 4775-4786, 2018.
APA
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X. ... Wang, Y. (2018). Mangiferin: An effective therapeutic agent against several disorders (Review). Molecular Medicine Reports, 18, 4775-4786. https://doi.org/10.3892/mmr.2018.9529
MLA
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., Wang, Y."Mangiferin: An effective therapeutic agent against several disorders (Review)". Molecular Medicine Reports 18.6 (2018): 4775-4786.
Chicago
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., Wang, Y."Mangiferin: An effective therapeutic agent against several disorders (Review)". Molecular Medicine Reports 18, no. 6 (2018): 4775-4786. https://doi.org/10.3892/mmr.2018.9529