Open Access

Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review)

  • Authors:
    • Kaixi Zhu
    • Qingqi Meng
    • Zhi Zhang
    • Tao Yi
    • Yuan He
    • Jing Zheng
    • Wei Lei
  • View Affiliations

  • Published online on: October 16, 2019     https://doi.org/10.3892/mmr.2019.10748
  • Pages: 4763-4773
  • Copyright : © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The aryl hydrocarbon receptor (AhR) is a ligand‑activated transcription factor originally isolated and characterized as the dioxin or xenobiotic receptor. With the discovery of endogenous ligands and studies of AhR knockout mice, AhR has been found to serve an important role in several biological processes, including immune responses and developmental and pathological regulation. In particular, it has been considered as a new major player in cardiovascular diseases. Recent studies have revealed that the development of atherosclerosis is closely associated with AhR function. However, the roles of the AhR in the pathological development of atherosclerosis and atherosclerosis‑associated diseases remain unclear. The current review presents the molecular mechanisms involved in the regulation of AhR expression during inflammation, oxidative stress and lipid deposition. Additionally, the role of the AhR in atherosclerosis and atherosclerosis‑associated diseases is reviewed.
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December-2019
Volume 20 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu K, Meng Q, Zhang Z, Yi T, He Y, Zheng J and Lei W: Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review). Mol Med Rep 20: 4763-4773, 2019.
APA
Zhu, K., Meng, Q., Zhang, Z., Yi, T., He, Y., Zheng, J., & Lei, W. (2019). Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review). Molecular Medicine Reports, 20, 4763-4773. https://doi.org/10.3892/mmr.2019.10748
MLA
Zhu, K., Meng, Q., Zhang, Z., Yi, T., He, Y., Zheng, J., Lei, W."Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review)". Molecular Medicine Reports 20.6 (2019): 4763-4773.
Chicago
Zhu, K., Meng, Q., Zhang, Z., Yi, T., He, Y., Zheng, J., Lei, W."Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review)". Molecular Medicine Reports 20, no. 6 (2019): 4763-4773. https://doi.org/10.3892/mmr.2019.10748