Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
- Authors:
- Wei Zhang
- Yu Zhang
- Jinke Fan
- Zhiguo Feng
- Xinqiang Song
-
Affiliations: College of Life Science, Xinyang Normal University, Xinyang, Henan 464000, P.R. China, School of Science, Qiongtai Normal University, Haikou, Hainan 571127, P.R. China - Published online on: January 15, 2024 https://doi.org/10.3892/mmr.2024.13162
- Article Number: 38
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Surh YJ and Lee SS: Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential. Life Sci. 56:1845–1855. 1995. View Article : Google Scholar : PubMed/NCBI | |
Higashiguchi F, Nakamura H, Hayashi H and Kometani T: Purification and structure determination of glucosides of capsaicin and dihydrocapsaicin from various Capsicum fruits. J Agric Food Chem. 54:5948–5953. 2006. View Article : Google Scholar : PubMed/NCBI | |
Cunha MR, Tavares MT, Fernandes TB and Parise-Filho R: Peppers: A ‘hot’ natural source for antitumor compounds. Molecules. 26:15212021. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Wang D, Huang J, Hu Y and Xu Y: Application of capsaicin as a potential new therapeutic drug in human cancers. J Clin Pharm Ther. 45:16–28. 2020. View Article : Google Scholar : PubMed/NCBI | |
Popescu GDA, Scheau C, Badarau IA, Dumitrache MD, Caruntu A, Scheau AE, Costache DO, Costache RS, Constantin C, Neagu M and Caruntu C: The effects of capsaicin on gastrointestinal cancers. Molecules. 26:942020. View Article : Google Scholar : PubMed/NCBI | |
Nanok K and Sansenya S: α-Glucosidase, α-amylase, and tyrosinase inhibitory potential of capsaicin and dihydrocapsaicin. J Food Biochem. 44:e130992020. View Article : Google Scholar : PubMed/NCBI | |
Katritzky AR, Xu YJ, Vakulenko AV, Wilcox AL and Bley KR: Model compounds of caged capsaicin: Design, synthesis, and photoreactivity. J Org Chem. 68:9100–9104. 2003. View Article : Google Scholar : PubMed/NCBI | |
Basith S, Cui M, Hong S and Choi S: Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules. 21:9662016. View Article : Google Scholar : PubMed/NCBI | |
Walpole CS, Bevan S, Bloomfield G, Breckenridge R, James IF, Ritchie T, Szallasi A, Winter J and Wrigglesworth R: Similarities and differences in the structure-activity relationships of capsaicin and resiniferatoxin analogues. J Med Chem. 39:2939–2952. 1996. View Article : Google Scholar : PubMed/NCBI | |
Srinivasan K: Antioxidant potential of spices and their active constituents. Crit Rev Food Sci Nutr. 54:352–372. 2014. View Article : Google Scholar : PubMed/NCBI | |
Naidu KA and Thippeswamy NB: Inhibition of human low density lipoprotein oxidation by active principles from spices. Mol Cell Biochem. 229:19–23. 2002. View Article : Google Scholar : PubMed/NCBI | |
Kursunluoglu G, Taskiran D and Kayali HA: The investigation of the antitumor agent toxicity and capsaicin effect on the electron transport chain enzymes, catalase activities and lipid peroxidation levels in lung, heart and brain tissues of rats. Molecules. 23:32672018. View Article : Google Scholar : PubMed/NCBI | |
Kogure K, Goto S, Nishimura M, Yasumoto M, Abe K, Ohiwa C, Sassa H, Kusumi T and Terada H: Mechanism of potent antiperoxidative effect of capsaicin. Biochim Biophys Acta. 1573:84–92. 2002. View Article : Google Scholar : PubMed/NCBI | |
Ochi T, Takaishi Y, Kogure K and Yamauti I: Antioxidant activity of a new capsaicin derivative from Capsicum annuum. J Nat Prod. 66:1094–1096. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kempaiah RK and Srinivasan K: Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats. Ann Nutr Metab. 48:314–320. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kempaiah RK and Srinivasan K: Antioxidant status of red blood cells and liver in hypercholesterolemic rats fed hypolipidemic spices. Int J Vitam Nutr Res. 74:199–208. 2004. View Article : Google Scholar : PubMed/NCBI | |
Qin Y, Ran L, Wang J, Yu L, Lang HD, Wang XL, Mi MT and Zhu JD: Capsaicin supplementation improved risk factors of coronary heart disease in individuals with low HDL-C levels. Nutrients. 9:10372017. View Article : Google Scholar : PubMed/NCBI | |
Nakagawa H and Hiura A: Capsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neurons. Anat Sci Int. 81:135–155. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ramsey IS, Delling M and Clapham DE: An introduction to TRP channels. Annu Rev Physiol. 68:619–647. 2006. View Article : Google Scholar : PubMed/NCBI | |
Knotkova H, Pappagallo M and Szallasi A: Capsaicin (TRPV1 Agonist) therapy for pain relief: Farewell or revival? Clin J Pain. 24:142–154. 2008. View Article : Google Scholar : PubMed/NCBI | |
Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, et al: Design and synthesis of new transient receptor potential vanilloid type-1 (TRPV1) channel modulators: Identification, molecular modeling analysis, and pharmacological characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a small molecule endowed with agonist TRPV1 Activity and protective effects against oxidative stress. ACS Chem Neurosci. 7:737–748. 2016. View Article : Google Scholar : PubMed/NCBI | |
Sharma SK, Vij AS and Sharma M: Mechanisms and clinical uses of capsaicin. Eur J Pharmacol. 720:55–62. 2013. View Article : Google Scholar : PubMed/NCBI | |
Lo Vecchio S, Andersen HH, Elberling J and Arendt-Nielsen L: Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia. Exp Brain Res. 239:2873–2886. 2021. View Article : Google Scholar : PubMed/NCBI | |
Gašparini D, Ljubičić R and Mršić-Pelčić J: Capsaicin-potential solution for chronic pain treatment. Psychiatr Danub. 32 (Suppl 4):S420–S428. 2020.PubMed/NCBI | |
Brown S, Simpson DM, Moyle G, Brew BJ, Schifitto G, Larbalestier N, Orkin C, Fisher M, Vanhove GF and Tobias JK: NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: Integrated analysis of two phase III, randomized, controlled trials. AIDS Res Ther. 10:52013. View Article : Google Scholar : PubMed/NCBI | |
Anand P and Bley K: Topical capsaicin for pain management: Therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth. 107:490–502. 2011. View Article : Google Scholar : PubMed/NCBI | |
Luongo L, Costa B, D'Agostino B, Guida F, Comelli F, Gatta L, Matteis M, Sullo N, De Petrocellis L, de Novellis V, et al: Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 66:243–250. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chapa-Oliver AM and Mejía-Teniente L: Capsaicin: From plants to a cancer-suppressing agent. Molecules. 21:9312016. View Article : Google Scholar : PubMed/NCBI | |
Merritt JC, Richbart SD, Moles EG, Cox AJ, Brown KC, Miles SL, Finch PT, Hess JA, Tirona MT, Valentovic MA and Dasgupta P: Anti-cancer activity of sustained release capsaicin formulations. Pharmacol Ther. 238:1081772022. View Article : Google Scholar : PubMed/NCBI | |
Akabori H, Yamamoto H, Tsuchihashi H, Mori T, Fujino K, Shimizu T, Endo Y and Tani T: Transient receptor potential vanilloid 1 antagonist, capsazepine, improves survival in a rat hemorrhagic shock model. Ann Surg. 245:964–970. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yoshioka M, St-Pierre S, Suzuki M and Tremblay A: Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr. 80:503–510. 1998. View Article : Google Scholar : PubMed/NCBI | |
Kang JH, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H and Yu R: Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice. J Med Food. 14:310–315. 2011. View Article : Google Scholar : PubMed/NCBI | |
Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW and Phillips SM: Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab (Lond). 7:652010. View Article : Google Scholar : PubMed/NCBI | |
Lejeune MPGM, Kovacs EMR and Westerterp-Plantenga MS: Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr. 90:651–659. 2003. View Article : Google Scholar : PubMed/NCBI | |
Lee GR, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH and Han IS: Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity (Silver Spring). 21:115–122. 2013. View Article : Google Scholar : PubMed/NCBI | |
Okumura T, Tsukui T, Hosokawa M and Miyashita K: Effect of caffeine and capsaicin on the blood glucose levels of obese/diabetic KK-A(y) mice. J Oleo Sci. 61:515–523. 2012. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Zhou Y and Fu J: Advances in antiobesity mechanisms of capsaicin. Curr Opin Pharmacol. 61:1–5. 2021. View Article : Google Scholar : PubMed/NCBI | |
Ward SM, Bayguinov J, Won KJ, Grundy D and Berthoud HR: Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol. 465:121–135. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ericson A, Nur EM, Petersson F and Kechagias S: The effects of capsaicin on gastrin secretion in isolated human antral glands: Before and after ingestion of red chilli. Dig Dis Sci. 54:491–498. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ohno T, Hattori Y, Komine R, Ae T, Mizuguchi S, Arai K, Saeki T, Suzuki T, Hosono K, Hayashi I, et al: Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Gastroenterology. 134:215–225. 2008. View Article : Google Scholar : PubMed/NCBI | |
Prakash UNS and Srinivasan K: Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats. Br J Nutr. 104:31–39. 2010. View Article : Google Scholar : PubMed/NCBI | |
Prakash UNS and Srinivasan K: Enhanced intestinal uptake of iron, zinc and calcium in rats fed pungent spice principles-piperine, capsaicin and ginger (Zingiber officinale). J Trace Elem Med Biol. 27:184–190. 2013. View Article : Google Scholar : PubMed/NCBI | |
Li Q, Li L, Wang F, Chen J, Zhao Y, Wang P, Nilius B, Liu D and Zhu Z: Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor δ activation. Pflugers Arch. 465:1303–1316. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Hu CP, Deng PY, Shen SS, Zhu HQ, Ding JS, Tan GS and Li YJ: The protective effects of rutaecarpine on gastric mucosa injury in rats. Planta Med. 71:416–419. 2005. View Article : Google Scholar : PubMed/NCBI | |
Akbar A, Yiangou Y, Facer P, Walters JR, Anand P and Ghosh S: Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut. 57:923–929. 2008. View Article : Google Scholar : PubMed/NCBI | |
Hardy J and Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science. 297:353–356. 2002. View Article : Google Scholar : PubMed/NCBI | |
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, et al: A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest. 113:1456–1464. 2004. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Sun BL, Xiang Y, Tian DY, Zhu C, Li WW, Liu YH, Bu XL, Shen LL, Jin WS, et al: Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. Transl Psychiatry. 10:2302020. View Article : Google Scholar : PubMed/NCBI | |
Shi Z, El-Obeid T, Riley M, Li M, Page A and Liu J: High chili intake and cognitive function among 4582 adults: An open cohort study over 15 years. Nutrients. 11:11832019. View Article : Google Scholar : PubMed/NCBI | |
Tyagi S, Shekhar N and Thakur AK: Protective role of capsaicin in neurological disorders: An overview. Neurochem Res. 47:1513–1531. 2022. View Article : Google Scholar : PubMed/NCBI | |
Li WH, Lee YM, Kim JY, Kang S, Kim S, Kim KH, Park CH and Chung JH: Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes. J Invest Dermatol. 127:2328–2335. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yu CS: Study on HIF-1α gene translation in psoriatic epidermis with the topical treatment of capsaicin ointment. ISRN Pharm. 2011:8218742011.PubMed/NCBI | |
Sekine R, Satoh T, Takaoka A, Saeki K and Yokozeki H: Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp Dermatol. 21:201–204. 2012. View Article : Google Scholar : PubMed/NCBI | |
Gooding SM, Canter PH, Coelho HF, Boddy K and Ernst E: Systematic review of topical capsaicin in the treatment of pruritus. Int J Dermatol. 49:858–865. 2010. View Article : Google Scholar : PubMed/NCBI | |
Back SK, Jeong KY, Li C, Lee J, Lee SB and Na HS: Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis. J Dermatol Sci. 67:111–119. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zahner MR, Li DP, Chen SR and Pan HL: Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol. 551:515–523. 2003. View Article : Google Scholar : PubMed/NCBI | |
Poblete IM, Orliac ML, Briones R, Adler-Graschinsky E and Huidobro-Toro JP: Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. J Physiol. 568:539–551. 2005. View Article : Google Scholar : PubMed/NCBI | |
Huang HS, Pan HL, Stahl GL and Longhurst JC: Ischemia- and reperfusion-sensitive cardiac sympathetic afferents: Influence of H2O2 and hydroxyl radicals. Am J Physiol. 269:H888–H901. 1995.PubMed/NCBI | |
Schultz HD and Ustinova EE: Capsaicin receptors mediate free radical-induced activation of cardiac afferent endings. Cardiovasc Res. 38:348–355. 1998. View Article : Google Scholar : PubMed/NCBI | |
Pan HL and Chen SR: Sensing tissue ischemia: Another new function for capsaicin receptors? Circulation. 110:1826–1831. 2004. View Article : Google Scholar : PubMed/NCBI | |
Steagall RJ, Sipe AL, Williams CA, Joyner WL and Singh K: Substance P release in response to cardiac ischemia from rat thoracic spinal dorsal horn is mediated by TRPV1. Neuroscience. 214:106–119. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ide R, Saiki C, Makino M and Matsumoto S: TRPV1 receptor expression in cardiac vagal afferent neurons of infant rats. Neurosci Lett. 507:67–71. 2012. View Article : Google Scholar : PubMed/NCBI | |
Jones WK, Fan GC, Liao S, Zhang JM, Wang Y, Weintraub NL, Kranias EG, Schultz JE, Lorenz J and Ren X: Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation. 120 (11 Suppl):S1–S9. 2009. View Article : Google Scholar : PubMed/NCBI | |
Wang L and Wang DH: TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation. 112:3617–3623. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sexton A, McDonald M, Cayla C, Thiemermann C and Ahluwalia A: 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1. FASEB J. 21:2695–2703. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yang D, Luo Z, Ma S, Wong WT, Ma L, Zhong J, He H, Zhao Z, Cao T, Yan Z, et al: Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab. 12:130–141. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chen Q, Zhu H, Zhang Y, Zhang Y, Wang L and Zheng L: Vasodilating effect of capsaicin on rat mesenteric artery and its mechanism. Zhejiang Da Xue Xue Bao Yi Xue Ban. 42:177–183. 2013.(In Chinese). PubMed/NCBI | |
Adams MJ, Ahuja KD and Geraghty DP: Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 124:721–723. 2009. View Article : Google Scholar : PubMed/NCBI | |
Mittelstadt SW, Nelson RA, Daanen JF, King AJ, Kort ME, Kym PR, Lubbers NL, Cox BF and Lynch JJ III: Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1. Blood Coagul Fibrinolysis. 23:94–97. 2012. View Article : Google Scholar : PubMed/NCBI | |
Raghavendra RH and Naidu KA: Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot Essent Fatty Acids. 81:73–78. 2009. View Article : Google Scholar : PubMed/NCBI | |
Sylvester DM and LaHann TR: Effects of capsaicinoids on platelet aggregation. Proc West Pharmacol Soc. 32:95–100. 1989.PubMed/NCBI | |
Meddings JB, Hogaboam CM, Tran K, Reynolds JD and Wallace JL: Capsaicin effects on non-neuronal plasma membranes. Biochim Biophys Acta. 1070:43–50. 1991. View Article : Google Scholar : PubMed/NCBI | |
Aranda FJ, Villalaín J and Gómez-Fernández JC: Capsaicin affects the structure and phase organization of phospholipid membranes. Biochim Biophys Acta. 1234:225–234. 1995. View Article : Google Scholar : PubMed/NCBI | |
Harper AG, Brownlow SL and Sage SO: A role for TRPV1 in agonist-evoked activation of human platelets. J Thromb Haemost. 7:330–338. 2009. View Article : Google Scholar : PubMed/NCBI | |
Batiha GE, Alqahtani A, Ojo OA, Shaheen HM, Wasef L, Elzeiny M, Ismail M, Shalaby M, Murata T, Zaragoza-Bastida A, et al: Biological properties, bioactive constituents, and pharmacokinetics of some Capsicum spp. and capsaicinoids. Int J Mol Sci. 21:51792020. View Article : Google Scholar : PubMed/NCBI | |
Jung SH, Kim HJ, Oh GS, Shen A, Lee S, Choe SK, Park R and So HS: Capsaicin ameliorates cisplatin-induced renal injury through induction of heme oxygenase-1. Mol Cells. 37:234–240. 2014. View Article : Google Scholar : PubMed/NCBI | |
Valentovic MA, Ball JG, Brown JM, Terneus MV, McQuade E, Van Meter S, Hedrick HM, Roy AA and Williams T: Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress. Toxicol In Vitro. 28:248–257. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y and Kizaki M: Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 64:1071–1078. 2004. View Article : Google Scholar : PubMed/NCBI | |
Mózsik G, Past T, Abdel Salam OM, Kuzma M and Perjési P: Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings. Inflammopharmacology. 17:113–150. 2009. View Article : Google Scholar : PubMed/NCBI | |
Luo XJ, Peng J and Li YJ: Recent advances in the study on capsaicinoids and capsinoids. Eur J Pharmacol. 650:1–7. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kang JY, Yeoh KG, Chia HP, Lee HP, Chia YW, Guan R and Yap I: Chili-protective factor against peptic ulcer? Dig Dis Sci. 40:576–579. 1995. View Article : Google Scholar : PubMed/NCBI | |
Chanda S, Bashir M, Babbar S, Koganti A and Bley K: In vitro hepatic and skin metabolism of capsaicin. Drug Metab Dispos. 36:670–675. 2008. View Article : Google Scholar : PubMed/NCBI | |
Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ and Yost GS: Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 16:336–349. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kawada T, Suzuki T, Takahashi M and Iwai K: Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol Appl Pharmacol. 72:449–456. 1984. View Article : Google Scholar : PubMed/NCBI | |
Wang YY, Hong CT, Chiu WT and Fang JY: In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. Int J Pharm. 224:89–104. 2001. View Article : Google Scholar : PubMed/NCBI | |
O'Neill J, Brock C, Olesen AE, Andresen T, Nilsson M and Dickenson AH: Unravelling the mystery of capsaicin: A tool to understand and treat pain. Pharmacol Rev. 64:939–971. 2012. View Article : Google Scholar : PubMed/NCBI | |
Suresh D and Srinivasan K: Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res. 131:682–691. 2010.PubMed/NCBI | |
Rollyson WD, Stover CA, Brown KC, Perry HE, Stevenson CD, McNees CA, Ball JG, Valentovic MA and Dasgupta P: Bioavailability of capsaicin and its implications for drug delivery. J Control Release. 196:96–105. 2014. View Article : Google Scholar : PubMed/NCBI | |
Thornton T, Mills D and Bliss E: Capsaicin: A potential treatment to improve cerebrovascular function and cognition in obesity and ageing. Nutrients. 15:15372023. View Article : Google Scholar : PubMed/NCBI | |
Petroianu GA, Aloum L and Adem A: Neuropathic pain: Mechanisms and therapeutic strategies. Front Cell Dev Biol. 11:10726292023. View Article : Google Scholar : PubMed/NCBI | |
Erin N and Szallasi A: Carcinogenesis and metastasis: Focus on TRPV1-positive neurons and immune cells. Biomolecules. 13:9832023. View Article : Google Scholar : PubMed/NCBI | |
Fernández-Carvajal A, Fernández-Ballester G and Ferrer-Montiel A: TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy. Front Mol Neurosci. 15:9309642022. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Angst E, Park JL, Moro A, Dawson DW, Reber HA, Eibl G, Hines OJ, Go VL and Lu QY: Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. J Agric Food Chem. 58:7252–7257. 2010. View Article : Google Scholar : PubMed/NCBI | |
Santos VAM, Bressiani PA, Zanotto AW, Almeida IV, Berti AP, Lunkes AM, Vicentini VEP and Düsman E: Cytotoxicity of capsaicin and its analogs in vitro. Braz J Biol. 83:e2689412023. View Article : Google Scholar : PubMed/NCBI | |
Chaiyasit K, Khovidhunkit W and Wittayalertpanya S: Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thai. 92:108–113. 2009.PubMed/NCBI | |
Braga Ferreira LG, Faria JV, Dos Santos JPS and Faria RX: Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities. Eur J Pharmacol. 887:1733562020. View Article : Google Scholar : PubMed/NCBI | |
Liu T, Wan Y, Meng Y, Zhou Q, Li B, Chen Y and Wang L: Capsaicin: A novel approach to the treatment of functional dyspepsia. Mol Nutr Food Res. 10:e22007932023. View Article : Google Scholar : PubMed/NCBI | |
Szallasi A: Capsaicin for weight control: ‘Exercise in a pill’ (or just another fad)? Pharmaceuticals (Basel). 15:8512022. View Article : Google Scholar : PubMed/NCBI | |
Huang Z, Sharma M, Dave A, Yang Y, Chen ZS and Radhakrishnan R: The antifibrotic and the anticarcinogenic activity of capsaicin in hot chili pepper in relation to oral submucous fibrosis. Front Pharmacol. 13:8882802022. View Article : Google Scholar : PubMed/NCBI | |
Malewicz NM, Rattray Z, Oeck S, Jung S, Escamilla-Rivera V, Chen Z, Tang X, Zhou J and LaMotte RH: Topical capsaicin in Poly(lactic-co-glycolic)acid (PLGA) nanoparticles decreases acute itch and heat pain. Int J Mol Sci. 23:52752022. View Article : Google Scholar : PubMed/NCBI | |
Yue WWS, Yuan L, Braz JM, Basbaum AI and Julius D: TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons. Elife. 11:e801392022. View Article : Google Scholar : PubMed/NCBI | |
Abbas MA: Modulation of TRPV1 channel function by natural products in the treatment of pain. Chem Biol Interact. 330:1091782020. View Article : Google Scholar : PubMed/NCBI | |
Yeon KY, Kim SA, Kim YH, Lee MK, Ahn DK, Kim HJ, Kim JS, Jung SJ and Oh SB: Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent Res. 89:170–174. 2010. View Article : Google Scholar : PubMed/NCBI | |
Sui F, Zhang CB, Yang N, Li LF, Guo SY, Huo HR and Jiang TL: Anti-nociceptive mechanism of baicalin involved in intervention of TRPV1 in DRG neurons in vitro. J Ethnopharmacol. 129:361–366. 2010. View Article : Google Scholar : PubMed/NCBI | |
Dludla PV, Nkambule BB, Cirilli I, Marcheggiani F, Mabhida SE, Ziqubu K, Ntamo Y, Jack B, Nyambuya TM, Hanser S and Mazibuko-Mbeje SE: Capsaicin, its clinical significance in patients with painful diabetic neuropathy. Biomed Pharmacother. 153:1134392022. View Article : Google Scholar : PubMed/NCBI |