Open Access

CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review)

  • Authors:
    • Dahua Sun
    • Xiang Shi
    • Sanyan Li
    • Xiaohua Wang
    • Xiao Yang
    • Meiping Wan
  • View Affiliations

  • Published online on: January 23, 2024     https://doi.org/10.3892/mmr.2024.13171
  • Article Number: 47
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chimeric antigen receptor (CAR)‑T cell therapy is an innovative approach to immune cell therapy that works by modifying the T cells of a patient to express the CAR protein on their surface, and thus induce their recognition and destruction of cancer cells. CAR‑T cell therapy has shown some success in treating hematological tumors, but it still faces a number of challenges in the treatment of solid tumors, such as antigen selection, tolerability and safety. In response to these issues, studies continue to improve the design of CAR‑T cells in pursuit of improved therapeutic efficacy and safety. In the future, CAR‑T cell therapy is expected to become an important cancer treatment, and may provide new ideas and strategies for individualized immunotherapy. The present review provides a comprehensive overview of the principles, clinical applications, therapeutic efficacy and challenges of CAR‑T cell therapy.
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March-2024
Volume 29 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Sun D, Shi X, Li S, Wang X, Yang X and Wan M: CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review). Mol Med Rep 29: 47, 2024.
APA
Sun, D., Shi, X., Li, S., Wang, X., Yang, X., & Wan, M. (2024). CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review). Molecular Medicine Reports, 29, 47. https://doi.org/10.3892/mmr.2024.13171
MLA
Sun, D., Shi, X., Li, S., Wang, X., Yang, X., Wan, M."CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review)". Molecular Medicine Reports 29.3 (2024): 47.
Chicago
Sun, D., Shi, X., Li, S., Wang, X., Yang, X., Wan, M."CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review)". Molecular Medicine Reports 29, no. 3 (2024): 47. https://doi.org/10.3892/mmr.2024.13171