Open Access

Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)

  • Authors:
    • Huonggiang Nguyen
    • Seon-Hwan Kim
    • Uijin Juang
    • Suhwan Gwon
    • Woohyeong Jung
    • Qingzhi Huang
    • Soohyeon Lee
    • Beomwoo Lee
    • So Hee Kwon
    • Jongsun Park
  • View Affiliations

  • Published online on: July 5, 2024     https://doi.org/10.3892/mmr.2024.13282
  • Article Number: 158
  • Copyright: © Nguyen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acyl‑coenzyme A thioesterases (ACOTs) are crucial in mediating lipid metabolic functions, including energy expenditure, hepatic gluconeogenesis and neuronal function. The two distinct types are type I and II ACOTs, the latter of which are ‘hotdog’ fold superfamily members. Type II ACOTs include carboxyl‑terminal modulator protein 1 (CTMP1), also termed thioesterase superfamily member 4 (THEM4), and CTMP2, also termed THEM5. Due to their similar structural features and distinct sequence homology, CTMP1 and CTMP2 stand out from other type II ACOTs. CTMP1 was initially known as a protein kinase B (PKB) inhibitor that attenuates PKB phosphorylation. PKB is the central regulator of various cellular functions, including survival, proliferation, growth and metabolism. Therefore, by inhibiting PKB, CTMP1 can affect various cellular processes. Various other functions of CTMP1 have been revealed, including functions in cancer, brain injury, mitochondrial function and lipid metabolism. CTMP2 is a paralog of CTMP1 and was first identified as a cardiolipin remodeling factor involved in the development of fatty liver. As the functions of CTMP1 and CTMP2 were discovered separately, a review to summarize and connect these findings is essential. The current review delineates the intricate complexity of CTMP regulation across different metabolic pathways and encapsulates the principal discoveries concerning CTMP until the present day.
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September-2024
Volume 30 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Nguyen H, Kim S, Juang U, Gwon S, Jung W, Huang Q, Lee S, Lee B, Kwon S, Park J, Park J, et al: Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review). Mol Med Rep 30: 158, 2024.
APA
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q. ... Park, J. (2024). Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review). Molecular Medicine Reports, 30, 158. https://doi.org/10.3892/mmr.2024.13282
MLA
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q., Lee, S., Lee, B., Kwon, S., Park, J."Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)". Molecular Medicine Reports 30.3 (2024): 158.
Chicago
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q., Lee, S., Lee, B., Kwon, S., Park, J."Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)". Molecular Medicine Reports 30, no. 3 (2024): 158. https://doi.org/10.3892/mmr.2024.13282