Open Access

Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review)

  • Authors:
    • Haichao Li
    • Donglian Liu
    • Kaishu Li
    • Yichen Wang
    • Gengqiang Zhang
    • Ling Qi
    • Keping Xie
  • View Affiliations

  • Published online on: July 5, 2024     https://doi.org/10.3892/mmr.2024.13283
  • Article Number: 159
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive form of cancer with a low survival rate. A successful treatment strategy should not be limited to targeting cancer cells alone, but should adopt a more comprehensive approach, taking into account other influential factors. These include the extracellular matrix (ECM) and immune microenvironment, both of which are integral components of the tumor microenvironment. The present review describes the roles of pancreatic stellate cells, differentiated cancer‑associated fibroblasts and the interleukin family, either independently or in combination, in the progression of precursor lesions in pancreatic intraepithelial neoplasia and PDAC. These elements contribute to ECM deposition and immunosuppression in PDAC. Therapeutic strategies that integrate interleukin and/or stromal blockade for PDAC immunomodulation and fibrogenesis have yielded inconsistent results. A deeper comprehension of the intricate interplay between fibrosis, and immune responses could pave the way for more effective treatment targets, by elucidating the mechanisms and causes of ECM fibrosis during PDAC progression.
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September-2024
Volume 30 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li H, Liu D, Li K, Wang Y, Zhang G, Qi L and Xie K: Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review). Mol Med Rep 30: 159, 2024.
APA
Li, H., Liu, D., Li, K., Wang, Y., Zhang, G., Qi, L., & Xie, K. (2024). Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review). Molecular Medicine Reports, 30, 159. https://doi.org/10.3892/mmr.2024.13283
MLA
Li, H., Liu, D., Li, K., Wang, Y., Zhang, G., Qi, L., Xie, K."Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review)". Molecular Medicine Reports 30.3 (2024): 159.
Chicago
Li, H., Liu, D., Li, K., Wang, Y., Zhang, G., Qi, L., Xie, K."Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review)". Molecular Medicine Reports 30, no. 3 (2024): 159. https://doi.org/10.3892/mmr.2024.13283