Open Access

Research progress on the anticancer effects of vitamin K2 (Review)

  • Authors:
    • Fan Xv
    • Jiepeng Chen
    • Lili Duan
    • Shuzhuang Li
  • View Affiliations

  • Published online on: April 16, 2018     https://doi.org/10.3892/ol.2018.8502
  • Pages: 8926-8934
  • Copyright: © Xv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite the availability of multiple therapeutic methods for patients with cancer, the long‑term prognosis is not satisfactory in a number of different cancer types. Vitamin K2 (VK2), which exerts anticancer effects on a number of cancer cell lines, is considered to be a prospective novel agent for the treatment of cancer. The present review aims to summarize the results of studies in which VK2 was administered either to patients with cancer or animals inoculated with cancerous cells, particularly investigating the inhibitory effects of VK2 on cancerous cells, primarily involving cell‑cycle arrest, cell differentiation, apoptosis, autophagy and invasion. The present review summarizes evidence stating that treatment with VK2 could positively inhibit the growth of cancer cells, making it a potentially useful approach for the prevention and clinical treatment of cancer. Additionally, the combination treatment of VK2 and established chemotherapeutics may achieve better results, with fewer side effects. Therefore, more attention should be paid to the effects of micronutrients on tumors.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xv F, Chen J, Duan L and Li S: Research progress on the anticancer effects of vitamin K2 (Review). Oncol Lett 15: 8926-8934, 2018.
APA
Xv, F., Chen, J., Duan, L., & Li, S. (2018). Research progress on the anticancer effects of vitamin K2 (Review). Oncology Letters, 15, 8926-8934. https://doi.org/10.3892/ol.2018.8502
MLA
Xv, F., Chen, J., Duan, L., Li, S."Research progress on the anticancer effects of vitamin K2 (Review)". Oncology Letters 15.6 (2018): 8926-8934.
Chicago
Xv, F., Chen, J., Duan, L., Li, S."Research progress on the anticancer effects of vitamin K2 (Review)". Oncology Letters 15, no. 6 (2018): 8926-8934. https://doi.org/10.3892/ol.2018.8502