Open Access

Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression

  • Authors:
    • Takuya Noda
    • Takeshi Fukuda
    • Eijiro Uchikura
    • Yuichiro Awazu
    • Takuma Wada
    • Reiko Tasaka
    • Makoto Yamauchi
    • Tomoyo Yasui
    • Toshiyuki Sumi
  • View Affiliations

  • Published online on: June 28, 2024     https://doi.org/10.3892/ol.2024.14547
  • Article Number: 414
  • Copyright: © Noda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer remains a significant global health concern despite advances in prevention and treatment. Current management for intermediate‑ to high‑risk stage IB‑IIB cervical cancer post‑radical hysterectomy involves irradiation or concurrent chemoradiation, although patients can exhibit several adverse events. Adjuvant chemotherapy has emerged as a promising alternative; however, its efficacy remains unclear. T‑box (TBX)2 is a transcription factor that is involved in the regulation of cell cycle progression during cancer and embryonic development. Additionally, elevated expression of TBX2 is associated with resistance to DNA‑damaging chemotherapeutic agents, such as cisplatin, carboplatin and doxorubicin. The aim of the present study was to investigate the relationship between TBX2 expression and recurrence in patients receiving adjuvant cisplatin and paclitaxel (TP) chemotherapy post‑radical hysterectomy. Additionally, the impact of TBX2 knockdown on cisplatin sensitivity was assessed in vitro. A retrospective analysis was performed on 100 patients. Patients were categorized into two groups based on recurrence within 2 years of treatment initiation: The non‑recurrent group (n=85) and the recurrent group (n=15). TBX2 expression was assessed immunohistochemically, and multiple logistic regression analysis was performed to identify predictors of recurrence. Additionally, the impact of small interfering RNA‑mediated TBX2 knockdown on cervical cancer cell sensitivity to cisplatin was evaluated. TBX2 expression was significantly higher in the recurrent group compared with that in the non‑recurrent group (P<0.01). Patients were stratified into low TBX2 expression (weighted score ≤8; n=80) and high TBX2 expression (weighted score ≥9; n=20) groups. The high TBX2 expression group exhibited a higher recurrence rate compared with the low expression group (P<0.01). Multivariate analysis identified TBX2 expression as an independent predictor of recurrence (P<0.01). Moreover, TBX2 knockdown significantly enhanced cervical cancer cell sensitivity to cisplatin in vitro (P<0.05). These findings highlight TBX2 expression as a potential predictive biomarker for recurrence amongst patients with intermediate‑ to high‑risk stage IB‑IIB cervical cancer receiving adjuvant TP chemotherapy post‑radical hysterectomy.
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September-2024
Volume 28 Issue 3

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Spandidos Publications style
Noda T, Fukuda T, Uchikura E, Awazu Y, Wada T, Tasaka R, Yamauchi M, Yasui T and Sumi T: Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression. Oncol Lett 28: 414, 2024.
APA
Noda, T., Fukuda, T., Uchikura, E., Awazu, Y., Wada, T., Tasaka, R. ... Sumi, T. (2024). Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression. Oncology Letters, 28, 414. https://doi.org/10.3892/ol.2024.14547
MLA
Noda, T., Fukuda, T., Uchikura, E., Awazu, Y., Wada, T., Tasaka, R., Yamauchi, M., Yasui, T., Sumi, T."Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression". Oncology Letters 28.3 (2024): 414.
Chicago
Noda, T., Fukuda, T., Uchikura, E., Awazu, Y., Wada, T., Tasaka, R., Yamauchi, M., Yasui, T., Sumi, T."Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression". Oncology Letters 28, no. 3 (2024): 414. https://doi.org/10.3892/ol.2024.14547