Open Access

Poorly cohesive gastric cancer with increased epithelial‑mesenchymal transition is associated with a poor prognosis

  • Authors:
    • Nobuhiro Nakazawa
    • Makoto Sohda
    • Munenori Ide
    • Yuki Shimoda
    • Akihiko Sano
    • Makoto Sakai
    • Tetsunari Oyama
    • Ken Shirabe
    • Hiroshi Saeki
  • View Affiliations

  • Published online on: July 3, 2024     https://doi.org/10.3892/ol.2024.14554
  • Article Number: 420
  • Copyright: © Nakazawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study examined the surgical outcome and prognosis of patients with poorly cohesive carcinoma (PCC), and characterized the molecular pathological factors, epithelial‑mesenchymal transition (EMT) and interstitial signals of the disease. A total of 281 patients who underwent gastric cancer (GC) surgery between April 2015 and August 2020 were included. Furthermore, tissue samples from another 197 patients with GC who underwent surgery between 1999 and 2003 were assessed using a tissue microarray. Preoperatively treated cases and endoscopic submucosal dissection cases were excluded, and multiple blocks containing the invasion region were collected for tissue microarray. For tissue microarray analysis, the clinicopathological factors of protein wnt3a (wnt3a), leucine‑rich repeat‑containing G‑protein coupled receptor 5, transforming growth factor‑β‑induced, phosphorylated serine/threonine‑protein kinase mTOR and E‑cadherin expression were collected as EMT markers. The results of the surgical case evaluation and tissue microarray indicated that PCC was more common in younger patients and women, as the ratio of women to men was higher in the PCC group compared with that in the non‑PCC group. However, none of the results revealed that the prognosis was worse in all patients with PCC compared with the non‑PCC group. Furthermore, in the tissue microarray study, PCC samples exhibited significantly decreased expression of the cell adhesion molecule E‑cadherin, suggesting enhanced EMT, which activates wnt3a signaling. PCC with increased EMT was significantly associated with a poor prognosis.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nakazawa N, Sohda M, Ide M, Shimoda Y, Sano A, Sakai M, Oyama T, Shirabe K and Saeki H: Poorly cohesive gastric cancer with increased epithelial‑mesenchymal transition is associated with a poor prognosis. Oncol Lett 28: 420, 2024.
APA
Nakazawa, N., Sohda, M., Ide, M., Shimoda, Y., Sano, A., Sakai, M. ... Saeki, H. (2024). Poorly cohesive gastric cancer with increased epithelial‑mesenchymal transition is associated with a poor prognosis. Oncology Letters, 28, 420. https://doi.org/10.3892/ol.2024.14554
MLA
Nakazawa, N., Sohda, M., Ide, M., Shimoda, Y., Sano, A., Sakai, M., Oyama, T., Shirabe, K., Saeki, H."Poorly cohesive gastric cancer with increased epithelial‑mesenchymal transition is associated with a poor prognosis". Oncology Letters 28.3 (2024): 420.
Chicago
Nakazawa, N., Sohda, M., Ide, M., Shimoda, Y., Sano, A., Sakai, M., Oyama, T., Shirabe, K., Saeki, H."Poorly cohesive gastric cancer with increased epithelial‑mesenchymal transition is associated with a poor prognosis". Oncology Letters 28, no. 3 (2024): 420. https://doi.org/10.3892/ol.2024.14554