Open Access

Rare primary intrapulmonary malignant peripheral nerve sheath tumor showing significant response to sintilimab: A case report and literature review

  • Authors:
    • Yunqi Chen
    • Ting Chen
    • Wanshan Zhu
    • Luzhen Li
    • Cantu Fang
    • Huatang Zhang
  • View Affiliations

  • Published online on: July 4, 2024     https://doi.org/10.3892/ol.2024.14556
  • Article Number: 423
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary pulmonary malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with a low incidence, poor prognosis and limited treatment options. The present study reported a case of lung MPNST in a 63‑year‑old male patient without any pulmonary symptoms. Immunohistochemical analysis of the tumor indicated a programmed death‑ligand 1 (PD‑L1) expression tumor proportion score of 60%. A total of six courses of sintilimab were used in this patient and a remarkable response was achieved. In summary, sintilimab single‑agent immunotherapy may be a novel treatment for pulmonary MPNST. When encountering analogous cases in the future, oncologists can test for the expression of PD‑L1 in patients to guide the therapy's design.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Y, Chen T, Zhu W, Li L, Fang C and Zhang H: Rare primary intrapulmonary malignant peripheral nerve sheath tumor showing significant response to sintilimab: A case report and literature review. Oncol Lett 28: 423, 2024.
APA
Chen, Y., Chen, T., Zhu, W., Li, L., Fang, C., & Zhang, H. (2024). Rare primary intrapulmonary malignant peripheral nerve sheath tumor showing significant response to sintilimab: A case report and literature review. Oncology Letters, 28, 423. https://doi.org/10.3892/ol.2024.14556
MLA
Chen, Y., Chen, T., Zhu, W., Li, L., Fang, C., Zhang, H."Rare primary intrapulmonary malignant peripheral nerve sheath tumor showing significant response to sintilimab: A case report and literature review". Oncology Letters 28.3 (2024): 423.
Chicago
Chen, Y., Chen, T., Zhu, W., Li, L., Fang, C., Zhang, H."Rare primary intrapulmonary malignant peripheral nerve sheath tumor showing significant response to sintilimab: A case report and literature review". Oncology Letters 28, no. 3 (2024): 423. https://doi.org/10.3892/ol.2024.14556