Open Access

Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation

  • Authors:
    • Laura Astolfi
    • Sara Ghiselli
    • Valeria Guaran
    • Milvia Chicca
    • Edi Simoni
    • Elena Olivetto
    • Giorgio Lelli
    • Alessandro Martini
  • View Affiliations

  • Published online on: February 6, 2013     https://doi.org/10.3892/or.2013.2279
  • Pages: 1285-1292
  • Copyright: © Astolfi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Cisplatin is the most common antineoplastic drug used for the therapy of solid tumours. To date, researchers have focused on the dosage to be administered for each specific tumour, mainly considering the local adverse effects. The aim of this study was to correlate the severity of the adverse effects with: i) the dosage of cisplatin; ii) the specific site of the tumour; iii) the association with other drugs; and iv) the symptoms. We analysed data from 123 patients with 11 different tumour classes undergoing therapy from 2007 to 2008 at St. Anna Hospital (Ferrara, Italy), using the Spearman non-parametric correlation index. Even though significant correlations were found among the variables, the overall results showed that the main factor influencing the severity of the adverse effects was the dosage of cisplatin administered.
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April 2013
Volume 29 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Astolfi L, Ghiselli S, Guaran V, Chicca M, Simoni E, Olivetto E, Lelli G and Martini A: Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation. Oncol Rep 29: 1285-1292, 2013.
APA
Astolfi, L., Ghiselli, S., Guaran, V., Chicca, M., Simoni, E., Olivetto, E. ... Martini, A. (2013). Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation. Oncology Reports, 29, 1285-1292. https://doi.org/10.3892/or.2013.2279
MLA
Astolfi, L., Ghiselli, S., Guaran, V., Chicca, M., Simoni, E., Olivetto, E., Lelli, G., Martini, A."Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation". Oncology Reports 29.4 (2013): 1285-1292.
Chicago
Astolfi, L., Ghiselli, S., Guaran, V., Chicca, M., Simoni, E., Olivetto, E., Lelli, G., Martini, A."Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation". Oncology Reports 29, no. 4 (2013): 1285-1292. https://doi.org/10.3892/or.2013.2279