The emerging landscape of circular RNA ciRS-7 in cancer (Review)

  • Authors:
    • Li Peng
    • Xiao Qing Yuan
    • Guan Cheng Li
  • View Affiliations

  • Published online on: April 8, 2015     https://doi.org/10.3892/or.2015.3904
  • Pages: 2669-2674
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Abstract

Circular RNAs (circRNAs) are a novel class of non‑coding RNA molecules ubiquitously present in the cytoplasm of eukaryotic cells. CircRNAs are generated from exons or introns via multiple mechanisms. A recently identified circRNA, ciRS-7, can regulate the activities of miRNAs, mRNAs, and RBP to exert specific biological effects. Also, ciRS-7 acts as a natural competing endogenous RNA, a.k.a. ‘super sponge’ of microRNA-7 (miR-7) that sequesters and competitively inhibits the activity of miR-7. This competition between ciRS-7 and miR-7 may have profound effects on oncogenesis. This review will summarize the origin and functions of ciRS-7 and discuss the relationship among ciRS-7, its target molecules and cancer.
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June-2015
Volume 33 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Peng L, Yuan XQ and Li GC: The emerging landscape of circular RNA ciRS-7 in cancer (Review). Oncol Rep 33: 2669-2674, 2015.
APA
Peng, L., Yuan, X.Q., & Li, G.C. (2015). The emerging landscape of circular RNA ciRS-7 in cancer (Review). Oncology Reports, 33, 2669-2674. https://doi.org/10.3892/or.2015.3904
MLA
Peng, L., Yuan, X. Q., Li, G. C."The emerging landscape of circular RNA ciRS-7 in cancer (Review)". Oncology Reports 33.6 (2015): 2669-2674.
Chicago
Peng, L., Yuan, X. Q., Li, G. C."The emerging landscape of circular RNA ciRS-7 in cancer (Review)". Oncology Reports 33, no. 6 (2015): 2669-2674. https://doi.org/10.3892/or.2015.3904