Open Access

Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

  • Authors:
    • Honglian Yu
    • Qiang Bian
    • Xin Wang
    • Xinzhe Wang
    • Luhao Lai
    • Zhichun Wu
    • Zhankui Zhao
    • Bo Ban
  • View Affiliations

  • Published online on: January 18, 2024     https://doi.org/10.3892/or.2024.8704
  • Article Number: 45
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone marrow stromal cell antigen 2 (BST2) is a type II transmembrane protein that serves critical roles in antiretroviral defense in the innate immune response. In addition, it has been suggested that BST2 is highly expressed in various types of human cancer and high BST2 expression is related to different clinicopathological parameters in cancer. The molecular mechanism underlying BST2 as a potential tumor biomarker in human solid tumors has been reported on; however, to the best of our knowledge, there has been no review published on the molecular mechanism of BST2 in human solid tumors. The present review focuses on human BST2 expression, structure and functions; the molecular mechanisms of BST2 in breast cancer, hepatocellular carcinoma, gastrointestinal tumor and other solid tumors; the therapeutic potential of BST2; and the possibility of BST2 as a potential marker. BST2 is involved in cell membrane integrity and lipid raft formation, which can activate epidermal growth factor receptor signaling pathways, providing a potential mechanistic link between BST2 and tumorigenesis. Notably, BST2 may be considered a universal tumor biomarker and a potential therapeutical target.
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March-2024
Volume 51 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yu H, Bian Q, Wang X, Wang X, Lai L, Wu Z, Zhao Z and Ban B: Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncol Rep 51: 45, 2024.
APA
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z. ... Ban, B. (2024). Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncology Reports, 51, 45. https://doi.org/10.3892/or.2024.8704
MLA
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z., Zhao, Z., Ban, B."Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)". Oncology Reports 51.3 (2024): 45.
Chicago
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z., Zhao, Z., Ban, B."Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)". Oncology Reports 51, no. 3 (2024): 45. https://doi.org/10.3892/or.2024.8704