Open Access

Important role and underlying mechanism of non‑SMC condensin I complex subunit G in tumours (Review)

  • Authors:
    • Ruobing Li
    • Dechun Wang
    • Hong Yang
    • Leilei Pu
    • Xiaohong Li
    • Fumei Yang
    • Rong Zhu
  • View Affiliations

  • Published online on: April 15, 2024     https://doi.org/10.3892/or.2024.8736
  • Article Number: 77
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

At present, the incidence of tumours is increasing on a yearly basis, and tumourigenesis is usually associated with chromosomal instability and cell cycle dysregulation. Moreover, abnormalities in the chromosomal structure often lead to DNA damage, further exacerbating gene mutations and chromosomal rearrangements. However, the non‑SMC condensin I complex subunit G (NCAPG) of the structural maintenance of chromosomes family is known to exert a key role in tumour development. It has been shown that high expression of NCAPG is closely associated with tumour development and progression. Overexpression of NCAPG variously affects chromosome condensation and segregation during cell mitosis, influences cell cycle regulation, promotes tumour cell proliferation and invasion, and inhibits apoptosis. In addition, NCAPG has been associated with tumour cell stemness, tumour resistance and recurrence. The aim of the present review was to explore the underlying mechanisms of NCAPG during tumour development, with a view towards providing novel targets and strategies for tumour therapy, and through the elucidation of the mechanisms involved, to lay the foundation for future developments in health.
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June-2024
Volume 51 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Li R, Wang D, Yang H, Pu L, Li X, Yang F and Zhu R: Important role and underlying mechanism of non‑SMC condensin I complex subunit G in tumours (Review). Oncol Rep 51: 77, 2024.
APA
Li, R., Wang, D., Yang, H., Pu, L., Li, X., Yang, F., & Zhu, R. (2024). Important role and underlying mechanism of non‑SMC condensin I complex subunit G in tumours (Review). Oncology Reports, 51, 77. https://doi.org/10.3892/or.2024.8736
MLA
Li, R., Wang, D., Yang, H., Pu, L., Li, X., Yang, F., Zhu, R."Important role and underlying mechanism of non‑SMC condensin I complex subunit G in tumours (Review)". Oncology Reports 51.6 (2024): 77.
Chicago
Li, R., Wang, D., Yang, H., Pu, L., Li, X., Yang, F., Zhu, R."Important role and underlying mechanism of non‑SMC condensin I complex subunit G in tumours (Review)". Oncology Reports 51, no. 6 (2024): 77. https://doi.org/10.3892/or.2024.8736