Open Access

Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review)

  • Authors:
    • Jia Wu
    • Ying Zhu
    • Dandan Liu
    • Qingwei Cong
    • Changchuan Bai
  • View Affiliations

  • Published online on: July 5, 2024     https://doi.org/10.3892/or.2024.8772
  • Article Number: 113
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, microRNAs (miRNAs or miRs) have been increasingly studied for their role in cancer and have shown potential as cancer biomarkers. miR‑143‑3p and miR‑143‑5p are the mature miRNAs derived from pre‑miRNA‑143. At present, there are numerous studies on the function of miR‑143‑3p in cancer progression, but there are no systematic reviews describing the function of miR‑143‑3p in cancer. It is widely considered that miR‑143‑3p is downregulated in most malignant tumors and that upstream regulators can act on this gene, which in turn regulates the corresponding target to act on the tumor. In addition, miRNA‑143‑3p can regulate target genes to affect the biological process of tumors through various signaling pathways, such as the PI3K/Akt, Wnt/β‑catenin, AKT/STAT3 and Ras‑Raf‑MEK‑ERK pathways. The present review comprehensively described the biogenesis of miR‑143‑3p, the biological functions of miR‑143‑3p and the related roles and mechanisms in different cancer types. The potential of miR‑143‑3p as a biomarker for cancer was also highlighted and valuable future research directions were discussed.
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September-2024
Volume 52 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wu J, Zhu Y, Liu D, Cong Q and Bai C: Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review). Oncol Rep 52: 113, 2024.
APA
Wu, J., Zhu, Y., Liu, D., Cong, Q., & Bai, C. (2024). Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review). Oncology Reports, 52, 113. https://doi.org/10.3892/or.2024.8772
MLA
Wu, J., Zhu, Y., Liu, D., Cong, Q., Bai, C."Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review)". Oncology Reports 52.3 (2024): 113.
Chicago
Wu, J., Zhu, Y., Liu, D., Cong, Q., Bai, C."Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review)". Oncology Reports 52, no. 3 (2024): 113. https://doi.org/10.3892/or.2024.8772