Open Access

Hedgehog pathway and cancer: A new area (Review)

  • Authors:
    • Deyi Shen
    • Yuwei Xia
    • Yuhan Fu
    • Qiaochang Cao
    • Wenqian Chen
    • Ying Zhu
    • Kaibo Guo
    • Leitao Sun
  • View Affiliations

  • Published online on: July 10, 2024     https://doi.org/10.3892/or.2024.8775
  • Article Number: 116
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In years of research on classical pathways, the composition, information transmission mechanism, crosstalk with other pathways, and physiological and pathological effects of hedgehog (HH) pathway have been gradually clarified. HH also plays a critical role in tumor formation and development. According to the update of interpretation of tumor phenotypes, the latest relevant studies have been sorted out, to explore the specific mechanism of HH pathway in regulating different tumor phenotypes through gene mutation and signal regulation. The drugs and natural ingredients involved in regulating HH pathway were also reviewed; five approved drugs and drugs under research exert efficacy by blocking HH pathway, and at least 22 natural components have potential to treat tumors by HH pathway. Nevertheless, there is a deficiency of existing studies. The present review confirmed the great potential of HH pathway in future cancer treatment with factual basis.
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September-2024
Volume 52 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Shen D, Xia Y, Fu Y, Cao Q, Chen W, Zhu Y, Guo K and Sun L: Hedgehog pathway and cancer: A new area (Review). Oncol Rep 52: 116, 2024.
APA
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y. ... Sun, L. (2024). Hedgehog pathway and cancer: A new area (Review). Oncology Reports, 52, 116. https://doi.org/10.3892/or.2024.8775
MLA
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y., Guo, K., Sun, L."Hedgehog pathway and cancer: A new area (Review)". Oncology Reports 52.3 (2024): 116.
Chicago
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y., Guo, K., Sun, L."Hedgehog pathway and cancer: A new area (Review)". Oncology Reports 52, no. 3 (2024): 116. https://doi.org/10.3892/or.2024.8775