Open Access

Reducing the amount of Clostridium difficile in the gut microbiome reduces the behavioral projection of cognitive activity in rats

  • Authors:
    • Gigi Tevzadze
    • Natalia Kiknadze
    • Elene Zhuravliova
    • Tamar Barbakadze
    • Lali Shanshiashvili
    • Nana Narmania
    • David Mikeladze
  • View Affiliations

  • Published online on: October 17, 2023     https://doi.org/10.3892/wasj.2023.207
  • Article Number: 30
  • Copyright : © Tevzadze et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

It is already known that the gut microbiome bacteria colony of Clostridium difficile produces 10‑1,000‑fold more para‑cresol (p‑cresol) than other known p‑cresol‑producing bacteria in the gut. A notable link between a high concentration of p‑cresol, a phenolic compound produced by Clostridium difficile, and its penetration into the brain and various neurological disorders has been demonstrated over the past decades. The present study demonstrates a possible link between the amounts of Clostridium difficile in the gut microbiome and p‑cresol levels in the brain with cognitive activity. Herein, the amount of Clostridium difficile in the gut microbiome of rats was decreased through administration of vancomycin, a well‑known antibiotic used for eliminating the effects of gut infections caused by the growth of the colony of Clostridium difficile. In these rats in the experimental group, the behavioral projection of cognitive activity was significantly decreased, compared to the rats in the control group. These data may thus indicate a potential link between Clostridium difficile colonies in the gut and cognitive functions of the brain. It is suggested that this interaction is carried out through the dopaminergic activity of the brain.
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November-December 2023
Volume 5 Issue 6

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Spandidos Publications style
Tevzadze G, Kiknadze N, Zhuravliova E, Barbakadze T, Shanshiashvili L, Narmania N and Mikeladze D: Reducing the amount of <em>Clostridium difficile</em> in the gut microbiome reduces the behavioral projection of cognitive activity in rats. World Acad Sci J 5: 30, 2023.
APA
Tevzadze, G., Kiknadze, N., Zhuravliova, E., Barbakadze, T., Shanshiashvili, L., Narmania, N., & Mikeladze, D. (2023). Reducing the amount of <em>Clostridium difficile</em> in the gut microbiome reduces the behavioral projection of cognitive activity in rats. World Academy of Sciences Journal, 5, 30. https://doi.org/10.3892/wasj.2023.207
MLA
Tevzadze, G., Kiknadze, N., Zhuravliova, E., Barbakadze, T., Shanshiashvili, L., Narmania, N., Mikeladze, D."Reducing the amount of <em>Clostridium difficile</em> in the gut microbiome reduces the behavioral projection of cognitive activity in rats". World Academy of Sciences Journal 5.6 (2023): 30.
Chicago
Tevzadze, G., Kiknadze, N., Zhuravliova, E., Barbakadze, T., Shanshiashvili, L., Narmania, N., Mikeladze, D."Reducing the amount of <em>Clostridium difficile</em> in the gut microbiome reduces the behavioral projection of cognitive activity in rats". World Academy of Sciences Journal 5, no. 6 (2023): 30. https://doi.org/10.3892/wasj.2023.207