Open Access

Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review)

  • Authors:
    • Cen Jin
    • Sijian Liao
    • Guoliang Lu
    • Bill D. Geng
    • Zi Ye
    • Jianwei Xu
    • Guo Ge
    • Dan Yang
  • View Affiliations

  • Published online on: July 8, 2024     https://doi.org/10.3892/mmr.2024.13286
  • Article Number: 162
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The treatment of patients with metastatic prostate cancer (PCa) is considered to be a long‑standing challenge. Conventional treatments for metastatic PCa, such as radical prostatectomy, radiotherapy and androgen receptor‑targeted therapy, induce senescence of PCa cells to a certain extent. While senescent cells can impede tumor growth through the restriction of cell proliferation and increasing immune clearance, the senescent microenvironment may concurrently stimulate the secretion of a senescence‑associated secretory phenotype and diminish immune cell function, which promotes PCa recurrence and metastasis. Resistance to established therapies is the primary obstacle in treating metastatic PCa as it can lead to progression towards an incurable state of disease. Therefore, understanding the molecular mechanisms that underly the progression of PCa is crucial for the development of novel therapeutic approaches. The present study reviews the phenomenon of treatment‑induced senescence in PCa, the dual role of senescence in PCa treatments and the mechanisms through which senescence promotes PCa metastasis. Furthermore, the present review discusses potential therapeutic strategies to target the aforementioned processes with the aim of providing insights into the evolving therapeutic landscape for the treatment of metastatic PCa.
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September-2024
Volume 30 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Jin C, Liao S, Lu G, Geng BD, Ye Z, Xu J, Ge G and Yang D: Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review). Mol Med Rep 30: 162, 2024.
APA
Jin, C., Liao, S., Lu, G., Geng, B.D., Ye, Z., Xu, J. ... Yang, D. (2024). Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review). Molecular Medicine Reports, 30, 162. https://doi.org/10.3892/mmr.2024.13286
MLA
Jin, C., Liao, S., Lu, G., Geng, B. D., Ye, Z., Xu, J., Ge, G., Yang, D."Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review)". Molecular Medicine Reports 30.3 (2024): 162.
Chicago
Jin, C., Liao, S., Lu, G., Geng, B. D., Ye, Z., Xu, J., Ge, G., Yang, D."Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review)". Molecular Medicine Reports 30, no. 3 (2024): 162. https://doi.org/10.3892/mmr.2024.13286