Open Access

Role of AMIGO2 in cancer progression: Novel insights (Review)

  • Authors:
    • Zhen Tian
    • Dongsheng Zhou
    • Rui Jiang
    • Bin Zhou
  • View Affiliations

  • Published online on: July 12, 2024     https://doi.org/10.3892/ol.2024.14567
  • Article Number: 434
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adhesion molecule with IgG‑like domain 2 (AMIGO2) is a novel scaffold protein initially identified in cerebellar granule neurons, and inhibits apoptosis of neurons. It is also widely expressed in various malignant tumors, including gastric cancer, colorectal carcinoma, ovarian cancer, prostate cancer and melanoma. During the past decades, it has been revealed that AMIGO2 can act as an oncogene, participating in tumor occurrence and development, for example by inhibiting apoptosis, accelerating cell proliferation, migration and adhesion, and promoting tumor metastasis and drug resistance. The present review discusses the recent advancements regarding AMIGO2 in the field of cancer, emphasizing its related molecular mechanisms to identify novel therapeutic strategies targeting AMIGO2 for cancer treatment in the future.
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September-2024
Volume 28 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Tian Z, Zhou D, Jiang R and Zhou B: Role of AMIGO2 in cancer progression: Novel insights (Review). Oncol Lett 28: 434, 2024.
APA
Tian, Z., Zhou, D., Jiang, R., & Zhou, B. (2024). Role of AMIGO2 in cancer progression: Novel insights (Review). Oncology Letters, 28, 434. https://doi.org/10.3892/ol.2024.14567
MLA
Tian, Z., Zhou, D., Jiang, R., Zhou, B."Role of AMIGO2 in cancer progression: Novel insights (Review)". Oncology Letters 28.3 (2024): 434.
Chicago
Tian, Z., Zhou, D., Jiang, R., Zhou, B."Role of AMIGO2 in cancer progression: Novel insights (Review)". Oncology Letters 28, no. 3 (2024): 434. https://doi.org/10.3892/ol.2024.14567