Open Access

Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma

  • Authors:
    • Hyun-Ji Kim
    • Min-Hye Ahn
    • Ji-Ae Shin
    • Su-Jung Choi
    • Hyun-Ju Yu
    • Sung-Dae Cho
  • View Affiliations

  • Published online on: December 11, 2023     https://doi.org/10.3892/or.2023.8680
  • Article Number: 21
  • Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypopharyngeal squamous cell carcinoma (HSCC) is a relatively rare form of head and neck cancer that is notorious for its poor prognosis and low overall survival rate. This highlights the need for new therapeutic options for this malignancy. The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat HSCC tumor growth. CAPE exerted its tumor‑suppressive activity in HSCC cell lines through the induction of apoptosis. Mechanistically, the CAPE‑mediated apoptotic process was attributed to the perturbation of the mitochondrial membrane potential and the activation of caspase‑9. CAPE also modulated survivin and X‑linked inhibitor of apoptosis, which are potent members of the inhibitors of apoptosis protein family, either through transcriptional or post‑translational regulation, leading to HSCC cell line death. Therefore, the findings of the present study suggested that CAPE is an effective treatment alternative for HSCC via the stimulation of mitochondria‑dependent apoptosis.
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February-2024
Volume 51 Issue 2

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Spandidos Publications style
Kim H, Ahn M, Shin J, Choi S, Yu H and Cho S: Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma. Oncol Rep 51: 21, 2024.
APA
Kim, H., Ahn, M., Shin, J., Choi, S., Yu, H., & Cho, S. (2024). Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma. Oncology Reports, 51, 21. https://doi.org/10.3892/or.2023.8680
MLA
Kim, H., Ahn, M., Shin, J., Choi, S., Yu, H., Cho, S."Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma". Oncology Reports 51.2 (2024): 21.
Chicago
Kim, H., Ahn, M., Shin, J., Choi, S., Yu, H., Cho, S."Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma". Oncology Reports 51, no. 2 (2024): 21. https://doi.org/10.3892/or.2023.8680